Licoflavone B | CAS:91433-17-9 | Manufacturer ChemFaces

Licoflavone B

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $114.2 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg

Asperosaponin VI

Catalog No: CFN99766
CAS No: 39524-08-8
Price: $30/20mg

Isorhamnetin-3-O-beta-D-Glucoside

Catalog No: CFN99757
CAS No: 5041-82-7
Price: $218/10mg

o-Methoxycinnamaldehyde

Catalog No: CFN93299
CAS No: 1504-74-1
Price: $40/20mg

Meloside A

Catalog No: CFN90132
CAS No: 60767-80-8
Price: $238/5mg

1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg

Isoliquiritin

Catalog No: CFN99155
CAS No: 5041-81-6
Price: $100/20mg

4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg

Oleuropein

Catalog No: CFN98416
CAS No: 32619-42-4
Price: $30/20mg

L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg

Description:

Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 uM) and ADPase (IC50 of 31.50 uM) inhibitory activities.

Targets:

Antifection | ATPase | ADPase

In vitro:

J Nat Prod. 2014 Mar 28;77(3):563-70.

Computer-guided approach to access the anti-influenza activity of licorice constituents.[Pubmed: 24313801 ]

Neuraminidase (NA), a key enzyme in viral replication, is the first-line drug target to combat influenza. On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs).
METHODS AND RESULTS:
Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), glabrone (5), hispaglabridin B (6), Licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.
CONCLUSIONS:
Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening.

In vivo:

Exp Parasitol. 2015 Dec;159:207-14.

Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae).[Pubmed: 26454044]

Schistosomiasis is one of the world's major public health problems, and its treatment is widely dependent on praziquantel (PZQ), the only available drug. Schistosoma mansoni ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of S. mansoni and considered an important target for action of new drugs.
METHODS AND RESULTS:
In this work, the in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots (GI) and its isolated compounds echinatin, licoflavone A and Licoflavone B were evaluated against S. mansoni adult worms. Results showed that GI (200 μg/mL) was active against adult schistosomes, causing 100% mortality after 24 h of incubation. Chromatographic fractionation of GI led to isolation of echinatin, licoflavone A and Licoflavone B. Licoflavone B (25-100 μM) caused 100% mortality, tegumental alterations, and reduction of oviposition and motor activity of all adult worms, without affecting mammalian Vero cells. Confocal laser scanning microscopy showed tegumental morphological alterations and changes on the numbers of tubercles of S. mansoni worms in a dose-dependent manner after incubation with Licoflavone B. Licoflavone B also showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. Docking studies predicted different interactions between Licoflavone B and S. mansoni ATPDase 1, corroborating with the in vitro inhibitory activity.
CONCLUSIONS:
This report demonstrated the first evidence for the schistosomicidal activity of Licoflavone B and suggests that its mechanism of action involve the inhibition of S. mansoni ATP diphosphohydrolases.

Licoflavone B Description

Source:	The roots of Glycyrrhiza inflata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Licoflavone B
Price:	$368 / 20mg
CAS No.:	91433-17-9
Catalog No.:	CFN93300
Molecular Formula:	C₂₅H₂₆O₄
Molecular Weight:	390.47 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Glycyrrhiza inflata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library ATPase Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.561 mL	12.8051 mL	25.6102 mL	51.2203 mL	64.0254 mL
5 mM	0.5122 mL	2.561 mL	5.122 mL	10.2441 mL	12.8051 mL
10 mM	0.2561 mL	1.2805 mL	2.561 mL	5.122 mL	6.4025 mL
50 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.0244 mL	1.2805 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.5122 mL	0.6403 mL

CFN93300	Licoflavone B	91433-17-9	390.47	C₂₅H₂₆O₄
CFN92289	Licoflavone C	72357-31-4	338.4	C₂₀H₁₈O₅
CFN97991	Atalantoflavone	119309-02-3	336.3	C₂₀H₁₆O₅
CFN95851	Albanin D	134955-26-3	406.5	C₂₅H₂₆O₅
CFN97161	4',5,7-Trihydroxy-6-prenylflavone	68097-13-2	338.4	C₂₀H₁₈O₅
CFN91417	5-Hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-3,4-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one	76288-44-3	338.4	C₂₀H₁₈O₅
CFN98969	Carpachromene	57498-96-1	336.3	C₂₀H₁₆O₅
CFN91901	Artocarpesin	3162-09-2	354.35	C₂₀H₁₈O₆
CFN90960	Multicaulisin	286461-76-5	692.71	C₄₀H₃₆O₁₁
CFN92228	Corylifol C	775351-91-2	338.4	C₂₀H₁₈O₅