Lucidin | CAS:478-08-0 | Manufacturer ChemFaces

Lucidin

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Description:

Lucidin and its derivatives are genotoxic, it is mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus.

Targets:

DNA/RNA Synthesis

In vitro:

Cell Biol Toxicol. 1988 Jun;4(2):225-39.

The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts.[Pubmed: 3069188]

The genotoxic activity of Lucidin (1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone), a natural component of Rubia tinctorum L., was tested in a battery of short-term tests.
METHODS AND RESULTS:
The compound was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, Lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture. We also investigated Lucidinethylether, which is formed from Lucidin by extraction of madder roots with boiling ethanol. This compound was also mutagenic in Salmonella, but only after addition of rat liver S9 mix. Lucidinethylether was weakly mutagenic to V79 cells which were cocultivated with rat hepatocytes. The compound did not induce DNA repair synthesis in hepatocytes from untreated rats, but positive results were obtained when hepatocytes from rats pretreated with phenobarbital were used.
CONCLUSIONS:
We conclude that Lucidin and its derivatives are genotoxic.

Lucidin Description

Source:	The roots of Rubia cordifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Lucidin
Price:
CAS No.:	478-08-0
Catalog No.:	CFN80213
Molecular Formula:	C₁₅H₁₀O₅
Molecular Weight:	270.05 g/mol
Purity:	>=98%
Type of Compound:	Anthraquinones
Physical Desc.:	Yellow powder
Source:	The roots of Rubia cordifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anthraquinones Compound Library DNA/RNA Synthesis Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.703 mL	18.5151 mL	37.0302 mL	74.0604 mL	92.5754 mL
5 mM	0.7406 mL	3.703 mL	7.406 mL	14.8121 mL	18.5151 mL
10 mM	0.3703 mL	1.8515 mL	3.703 mL	7.406 mL	9.2575 mL
50 mM	0.0741 mL	0.3703 mL	0.7406 mL	1.4812 mL	1.8515 mL
100 mM	0.037 mL	0.1852 mL	0.3703 mL	0.7406 mL	0.9258 mL

CFN92112	2-Hydroxy-3-(hydroxymethyl)anthraquinone	68243-30-1	254.2	C₁₅H₁₀O₄
CFN92536	Digiferruginol	24094-45-9	254.2	C₁₅H₁₀O₄
CFN92570	Tectoquinone	84-54-8	222.2	C₁₅H₁₀O₂
CFN99810	2-Hydroxy-3-methylanthraquinone	17241-40-6	238.2	C₁₅H₁₀O₃
CFN92567	1-Hydroxy-2-methylanthraquinone	6268-09-3	238.2	C₁₅H₁₀O₃
CFN92558	1,2-dihydroxy-3-methyl-anthracene-9,10-dione	602-63-1	254.2	C₁₅H₁₀O₄
CFN92109	Digitolutein	477-86-1	268.3	C₁₆H₁₂O₄
CFN97227	Rubiadin 1-methyl ether	7460-43-7	268.3	C₁₆H₁₂O₄
CFN99270	Rubiadin	117-02-2	254.2	C₁₅H₁₀O₄
CFN80213	Lucidin	478-08-0	270.05	C₁₅H₁₀O₅