Science | Nature | Cell | View More
Natural Products
Coronaridine
Coronaridine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Coronaridine
Price:
CAS No.: 467-77-6
Catalog No.: CFN92859
Molecular Formula: C21H26N2O2
Molecular Weight: 338.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Ervatamia divaricata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad Miguel Hernández (Spain)
  • MTT Agrifood Research Finland (Finland)
  • University of Perugia (Italy)
  • Centralised Purchases Unit (CPU... (India)
  • Hamdard University (India)
  • Deutsches Krebsforschungszentrum (Germany)
  • Johannes Gutenberg University M... (Germany)
  • Chang Gung University (Taiwan)
  • Complutense University of Madrid (Spain)
  • Mendel University in Brno (Czech Republic)
  • University of Eastern Finland (Finland)
  • More...
Package
Featured Products
Syringaresinol-di-O-glucoside

Catalog No: CFN90458
CAS No: 66791-77-3
Price: $138/20mg
Liensinine

Catalog No: CFN99580
CAS No: 2586-96-1
Price: $100/20mg
Vitexicarpin

Catalog No: CFN98172
CAS No: 479-91-4
Price: $80/20mg
D-(-)-Salicin

Catalog No: CFN99541
CAS No: 138-52-3
Price: $30/20mg
beta-Amyrin acetate

Catalog No: CFN99679
CAS No: 1616-93-9
Price: $ /
Agrimol B

Catalog No: CFN98169
CAS No: 55576-66-4
Price: $138/20mg
Lobetyolin

Catalog No: CFN99104
CAS No: 136085-37-5
Price: $168/20mg
Atractylodin

Catalog No: CFN99535
CAS No: 55290-63-6
Price: $60/20mg
Pristimerin

Catalog No: CFN90169
CAS No: 1258-84-0
Price: $128/20mg
Pelargonidin-3-O-glucoside chloride

Catalog No: CFN92134
CAS No: 18466-51-8
Price: $490/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Coronaridine is an antitumor agent. Coronaridine congeners inhibit hα3β4 AChRs by blocking the ion channel's lumen and probably by additional negative allosteric mechanisms by interacting with a series of non-luminal sites.
Targets: AChR
In vitro:
Int J Biochem Cell Biol. 2015 Aug;65:81-90.
Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites.[Pubmed: 26022277]
To characterize the interaction of Coronaridine congeners with human (h) α3β4 nicotinic acetylcholine receptors (AChRs), structural and functional approaches were used.
METHODS AND RESULTS:
The Ca(2+) influx results established that Coronaridine congeners noncompetitively inhibit hα3β4 AChRs with the following potency (IC50's in μM) sequence: (-)-ibogamine (0.62±0.23)∼(+)-catharanthine (0.68±0.10)>(-)-ibogaine (0.95±0.10)>(±)-18-methoxyCoronaridine [(±)-18-MC] (1.47±0.21)>(-)-voacangine (2.28±0.33)>(±)-18-methylaminoCoronaridine (2.62±0.57 μM)∼(±)-18-hydroxyCoronaridine (2.81±0.54)>(-)-noribogaine (6.82±0.78). A good linear correlation (r(2)=0.771) between the calculated IC50 values and their polar surface area was found, suggesting that this is an important structural feature for its activity. The radioligand competition results indicate that (±)-18-MC and (-)-ibogaine partially inhibit [(3)H]imipramine binding by an allosteric mechanism. Molecular docking, molecular dynamics, and in silico mutation results suggest that protonated (-)-18-MC binds to luminal [i.e., β4-Phe255 (phenylalanine/valine ring; position 13'), and α3-Leu250 and β4-Leu251 (leucine ring; position 9')], non-luminal, and intersubunit sites. The pharmacophore model suggests that nitrogens from the ibogamine core as well as methylamino, hydroxyl, and methoxyl moieties at position 18 form hydrogen bonds.
CONCLUSIONS:
Collectively our data indicate that Coronaridine congeners inhibit hα3β4 AChRs by blocking the ion channel's lumen and probably by additional negative allosteric mechanisms by interacting with a series of non-luminal sites.
Genet Mol Biol. 2013 Mar;36(1):105-10.
Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2).[Pubmed: 23569415]
Such as heyneanine, Coronaridine and voacangine.
METHODS AND RESULTS:
The aim of present study was firstly to screen the cytotoxic activity of the indole alkaloids heyneanine, Coronaridine and voacangine against HeLa (human cervix tumor), 3T3 (normal mouse embryo fibroblasts), Hep-2 (human laryngeal epithelial carcinoma) and B-16 (murine skin) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); and secondly to analyze the apoptotic activity, cell membrane damage and genotoxicity of the compound that showed the best cytotoxic activity against the tumor cell lines tested. Coronaridine was the one that exhibited greater cytotoxic activity in the laryngeal carcinoma cell line Hep-2 (IC50 = 54.47 μg/mL) than the other alkaloids tested (voacangine IC50 = 159.33 g/mL, and heyneanine IC50 = 689.45 μg/mL). Coronaridine induced apoptosis in cell lines 3T3 and Hep-2, even at high concentrations. The evaluation of genotoxicity by comet assay showed further that Coronaridine caused minimal DNA damage in the Hep-2 tumor cell line, and the LDH test showed that it did not affect the plasma membrane.
CONCLUSIONS:
These results suggest that further investigation of Coronaridine as an antitumor agent has merit.
Coronaridine Description
Source: The herbs of Ervatamia divaricata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isorhamnetin 3,5-O-diglucoside

Catalog No: CFN95488
CAS No: 2035413-03-5
Price: $318/10mg
Peltatoside 7-O-beta-glucopyranosi...

Catalog No: CFN95565
CAS No: 813466-12-5
Price: $318/20mg
5-Hydroxy-7-(4'-hydroxy-3'-methoxy...

Catalog No: CFN95135
CAS No: 79559-61-8
Price: $268/20mg
Astin B

Catalog No: CFN95188
CAS No: 151201-76-2
Price: $318/10mg
Methyl lucidenate G

Catalog No: CFN95058
CAS No: 102607-20-5
Price: $413/5mg
Stevioside D

Catalog No: CFN95230
CAS No: 1310055-59-4
Price: $463/5mg
New compound 6

Catalog No: CFN95259
CAS No: N/A
Price: $413/5mg
Astin A

Catalog No: CFN95187
CAS No: 151201-75-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9551 mL 14.7754 mL 29.5508 mL 59.1017 mL 73.8771 mL
5 mM 0.591 mL 2.9551 mL 5.9102 mL 11.8203 mL 14.7754 mL
10 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
50 mM 0.0591 mL 0.2955 mL 0.591 mL 1.182 mL 1.4775 mL
100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Syringaresinol-di-O-glucoside

Catalog No: CFN90458
CAS No: 66791-77-3
Price: $138/20mg
Liensinine

Catalog No: CFN99580
CAS No: 2586-96-1
Price: $100/20mg
Vitexicarpin

Catalog No: CFN98172
CAS No: 479-91-4
Price: $80/20mg
D-(-)-Salicin

Catalog No: CFN99541
CAS No: 138-52-3
Price: $30/20mg
beta-Amyrin acetate

Catalog No: CFN99679
CAS No: 1616-93-9
Price: $ /
Agrimol B

Catalog No: CFN98169
CAS No: 55576-66-4
Price: $138/20mg
Lobetyolin

Catalog No: CFN99104
CAS No: 136085-37-5
Price: $168/20mg
Atractylodin

Catalog No: CFN99535
CAS No: 55290-63-6
Price: $60/20mg
Pristimerin

Catalog No: CFN90169
CAS No: 1258-84-0
Price: $128/20mg
Pelargonidin-3-O-glucoside chloride

Catalog No: CFN92134
CAS No: 18466-51-8
Price: $490/10mg
Tags: buy Coronaridine | Coronaridine supplier | purchase Coronaridine | Coronaridine cost | Coronaridine manufacturer | order Coronaridine | Coronaridine distributor