Luvangetin | CAS:483-92-1 | Manufacturer ChemFaces

Luvangetin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs.

Targets:

NO | PGE | COX | Antifection

In vitro:

Pharm Biol. 2017 Dec;55(1):1195-1201.

Anti-inflammatory coumarins from Paramignya trimera.[Pubmed: 28245363 ]

METHODS AND RESULTS:
Seven coumarins were isolated and identified as: ostruthin (1), ninhvanin (2), 8-geranyl-7-hydroxycoumarin (3), 6-(6',7'-dihydroxy-3',7'-dimethylocta-2'-enyl)-7-hydroxycoumarin (4), 6-(7-hydroperoxy-3,7-dimethylocta-2,5-dienyl)-7-hydroxycoumarin (5), 6-(2-hydroxyethyl)-2,2-dimethyl-2H-1-benzopyran (6), and Luvangetin (7). Compounds 1-4 and 7 inhibited NO and PGE2 production in LPS-stimulated BV2 cells, with IC50 values ranging from 9.8 to 46.8 and from 9.4 to 52.8 μM, respectively. Ostruthin (1) and ninhvanin (2) were shown to suppress LPS-induced iNOS and COX-2 protein expression.
CONCLUSIONS:
The present study provides a scientific rationale for the use of P. trimera in the prevention and treatment of neuroinflammatory diseases. Ostruthin and ninhvanin might have potential therapeutic effects and should be considered for further development as new anti-neuroinflammatory agents.

In vivo:

Indian J Exp Biol. 1997 Oct;35(10):1080-3.

Antiulcer activity of naturally occurring pyrano-coumarin and isocoumarins and their effect on prostanoid synthesis using human colonic mucosa.[Pubmed: 9475044]

METHODS AND RESULTS:
Oral administration of bergenin and norbergenin, two isocoumarins, isolated from the leaves and roots of Flueggea microcarpa and Luvangetin, a pyranocoumarin isolated from the seeds of Aegle marmelos Correa, showed significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs. The study on prostaglandins release by human colonic mucosal incubates, indicated a concentration-dependent (1-10 micrograms/ml) stimulatory effect of bergenin and norbergenin, while Luvangetin (1-10 micrograms/ml) did not produce any effect.
CONCLUSIONS:
The results suggest that gastroprotective effects of bergenin and norbergenin could be due to increased prostaglandin production while, some other mucosal defensive factors may be involved for Luvangetin.

Luvangetin Description

Source:	The seeds of Aegle marmelos Correa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Luvangetin
Price:
CAS No.:	483-92-1
Catalog No.:	CFN89243
Molecular Formula:	C₁₅H₁₄O₄
Molecular Weight:	258.27 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The seeds of Aegle marmelos Correa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Anti-ticulcer Compound Library Coumarins Compound Library PGE Inhibitor Library NO Inhibitor Library COX Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8719 mL	19.3596 mL	38.7192 mL	77.4383 mL	96.7979 mL
5 mM	0.7744 mL	3.8719 mL	7.7438 mL	15.4877 mL	19.3596 mL
10 mM	0.3872 mL	1.936 mL	3.8719 mL	7.7438 mL	9.6798 mL
50 mM	0.0774 mL	0.3872 mL	0.7744 mL	1.5488 mL	1.936 mL
100 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.7744 mL	0.968 mL

CFN99629	Micromelin	15085-71-9	288.3	C₁₅H₁₂O₆
CFN89277	Hydramicromelin B	369391-55-9	306.27	C₁₅H₁₄O₇
CFN89265	Hydramicromelin D	1623437-86-4	306.27	C₁₅H₁₄O₇
CFN96429	Xanthyletin	553-19-5	228.24	C₁₄H₁₂O₃
CFN96284	Xanthoxyletin	84-99-1	258.3	C₁₅H₁₄O₄
CFN89243	Luvangetin	483-92-1	258.27	C₁₅H₁₄O₄
CFN89286	Demethylluvangetin	64652-10-4	244.24	C₁₄H₁₂O₄
CFN91704	3'-Hydroxyxanthyletin	165900-08-3	244.2	C₁₄H₁₂O₄
CFN92775	3',4'-dihydro-3'-hydroxy-Xanthyletin	5993-18-0	246.3	C₁₄H₁₄O₄
CFN90496	Decursinol	23458-02-8	246.26	C₁₄H₁₄O₄