Structure Identification: |
Fitoterapia. 2014 Dec;99:92-8. | Neolignans, lignans and glycoside from the fruits of Melia toosendan.[Pubmed: 25250895 ] | Four new neolignans, meliasendanin A, meliasendanin B, meliasendanin C,Meliasendanin D (1-4), and a new glycoside, toosenoside A (5), together with ten known ones (6-15), were isolated from a n-BuOH partition of the fruits of Melia toosendan.
METHODS AND RESULTS:
Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis.
The antioxidant activity of the isolated neolignans and lignans was evaluated by ABTS radical-scavenging assay.
CONCLUSIONS:
Compounds 1 and 13 exhibited strong antioxidant activity, with IC₅₀ values of 62.8 and 45.1 μM, respectively. |
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