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Mesuaxanthone A
Mesuaxanthone A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Mesuaxanthone A
Price:
CAS No.: 3561-81-7
Catalog No.: CFN98472
Molecular Formula: C14H10O5
Molecular Weight: 258.2 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Source: The herbs of Calophyllum inophyllum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and ether anaerthesia in mice and rats; they also exhibit anti inflammatory activity both by intraperitoneal and oral routes in rats.
In vivo:
Indian J.Pharmacol., 1980,12(3):181-91.
Anti-inflammatory and C.N.S. depressant activities of xanthones from Calophyllum inophyllum and Mesua ferrea[Reference: WebLink]
The xanthones of Calophyllum inophyllum and Mesua Ferrea namely, dehydrocycloguanandin (DCG), calophyllin-B (CPB), jacareubin (JR), 6-desoxy jacareubin (DJR), Mesuaxanthone A (MXA), Mesuaxanthone B (MXB) and euxanthone (EX) were screened for various pharmacological effects in experimental animals.
METHODS AND RESULTS:
All the xanthones produced varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and ether anaerthesia in mice and rats.None of the xanthones had any analgesic, antipyretic and anticonvulsant activities. The xanthones did not produce any pharmacological effect in the cardiovascular system of frogs and dogs. All the xanthones exhibited anti inflammatory activity both by intraperitoneal and oral routes in rats as tested by carrageenin induced hind paw oedema, cotton pellet granuloma and granuloma pouch techniques, in normal and adrenalectomised rats.
CONCLUSIONS:
The xanthones did not have any mast cell membrane stabilising effect, and the degranulating effect of compound 48/80, diazoxide and Won-X-100 on rat peritoneal mast cells in vitro war not prevented. JR and DJR exhibited antiulcer activity in rats. The xanthones did not alter the prothrombin time in rats.
Mesuaxanthone A Description
Source: The herbs of Calophyllum inophyllum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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IF=13.903(2019)

PMID: 29553709

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.873 mL 19.3648 mL 38.7297 mL 77.4593 mL 96.8242 mL
5 mM 0.7746 mL 3.873 mL 7.7459 mL 15.4919 mL 19.3648 mL
10 mM 0.3873 mL 1.9365 mL 3.873 mL 7.7459 mL 9.6824 mL
50 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.5492 mL 1.9365 mL
100 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7746 mL 0.9682 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron,1967,23(1):243–248.
Constituents of Mesua ferrea L.—I : Mesuaxanthone A and mesuaxanthone B[Reference: WebLink]

METHODS AND RESULTS:
Two new yellow pigments, Mesuaxanthone A and mesuaxanthone B, and the known euxanthone have been isolated from the heartwood extracts of Mesua ferrea L.
CONCLUSIONS:
Evidence is presented to show that Mesuaxanthone A is 1,5-dihydroxy-3-methoxy-xanthone and mesuaxanthone B is 1,5,6-trihydroxyxanthone. Mesuaxanthone A has been synthesized.
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