Methyl demethoxycarbonylchanofruticosinate | CAS:80151-89-9

Methyl demethoxycarbonylchanofruticosinate

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Description:

Methyl demethoxycarbonylchanofruticosinate exhibits significant antitussive activity in a citric acid induced guinea pig cough model.

In vivo:

Planta Med. 2011 Jun;77(9):939-44.

Antitussive indole alkaloids from Kopsia hainanensis.[Pubmed: 21165819]

METHODS AND RESULTS:
Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and Methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and Methyl demethoxycarbonylchanofruticosinate exhibited significant antitussive activity in a citric acid induced guinea pig cough model.
CONCLUSIONS:
The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor.This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.

Methyl demethoxycarbonylchanofruticosinate Description

Source:	The herbs of Kopsia hainanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Methyl demethoxycarbonylchanofruticosinate
Price:
CAS No.:	80151-89-9
Catalog No.:	CFN97275
Molecular Formula:	C₂₁H₂₄N₂O₃
Molecular Weight:	352.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Kopsia hainanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antitussive Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8377 mL	14.1884 mL	28.3768 mL	56.7537 mL	70.9421 mL
5 mM	0.5675 mL	2.8377 mL	5.6754 mL	11.3507 mL	14.1884 mL
10 mM	0.2838 mL	1.4188 mL	2.8377 mL	5.6754 mL	7.0942 mL
50 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.1351 mL	1.4188 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.5675 mL	0.7094 mL

CFN96107	Apparicine	2122-36-3	264.4	C₁₈H₂₀N₂
CFN97329	Ibogaine	83-74-9	310.4	C₂₀H₂₆N₂O
CFN96649	Tabernanthine	83-94-3	310.44	C₂₀H₂₆N₂O
CFN92252	Voacangine	510-22-5	368.5	C₂₂H₂₈N₂O₃
CFN96068	Conopharyngine	76-98-2	398.5	C₂₃H₃₀N₂O₄
CFN96069	19(S)-Hydroxyconopharyngine	16790-93-5	414.5	C₂₃H₃₀N₂O₅
CFN96176	Crassanine	16790-92-4	414.5	C₂₃H₃₀N₂O₅
CFN99765	Catharanthine	2468-21-5	336.43	C₂₁H₂₄N₂O₂
CFN90318	Catharanthine Tartrate	2648-21-5	486.40	C₂₁H₂₄N₂O₂.C₄H₆O₆
CFN93298	Catharanthine Sulfate	70674-90-7	434.51	C₂₁H₂₆N₂O₆S