Methyl sinapate | CAS:20733-94-2 | Manufacturer ChemFaces

Methyl sinapate

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Description:

Methyl sinapate can increase the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV.

In vitro:

Mutat Res. 1989 Jun;212(2):213-21.

Enhancing effects of cinoxate and methyl sinapate on the frequencies of sister-chromatid exchanges and chromosome aberrations in cultured mammalian cells.[Pubmed: 2499777]

METHODS AND RESULTS:
Sister-chromatid exchanges (SCEs) induced by mitomycin C (MMC), 4-nitroquinoline-1-oxide (4NQO) or UV-light in cultured Chinese hamster ovary cells (CHO K-1 cells) were enhanced by cinoxate (2-ethoxyethyl p-methoxycinnamate) or Methyl sinapate (methyl 3,5-dimethoxy 4-hydroxycinnamate). Both substances are cinnamate derivatives and cinoxate is commonly used as a cosmetic UV absorber. Methyl sinapate also increased the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV. These increasing effects of Methyl sinapate were critical in the G1 phase of the cell cycle and the decline of the frequencies of UV-induced SCEs and chromosome aberrations during liquid holding was not seen in the presence of Methyl sinapate. Both compounds were, however, ineffective in cells treated with X-rays. In cells from a normal human embryo and from a xeroderma pigmentosum (XP) patient, MMC-induced SCEs were also increased by the post-treatment with Methyl sinapate. The SCE frequencies in UV-irradiated normal human cells were elevated by Methyl sinapate, but no SCE-enhancing effects were observed in UV-irradiated XP cells.
CONCLUSIONS:
Our results suggest that the test substances inhibit DNA excision repair and that the increase in the amount of unrepaired DNA damage might cause the enhancement of induced SCEs and chromosome aberrations.

Methyl sinapate Description

Source:	The herbs of Rauvolfia tetraphylla
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Methyl sinapate
Price:	$80 / 20mg
CAS No.:	20733-94-2
Catalog No.:	CFN97787
Molecular Formula:	C₁₂H₁₄O₅
Molecular Weight:	238.24 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Powder
Source:	The herbs of Rauvolfia tetraphylla
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Teratogens Compound Library Phenylpropanoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	83.949 mL	104.9362 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	16.7898 mL	20.9872 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	8.3949 mL	10.4936 mL
50 mM	0.0839 mL	0.4197 mL	0.8395 mL	1.679 mL	2.0987 mL
100 mM	0.042 mL	0.2099 mL	0.4197 mL	0.8395 mL	1.0494 mL

CFN70250	trans-5-Hydroxyferulic acid	110642-42-7	210.2	C₁₀H₁₀O₅
CFN91507	Sinapyl alcohol	537-33-7	210.2	C₁₁H₁₄O₄
CFN70106	trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde	4206-58-0	208.2	C₁₁H₁₂O₄
CFN92631	Sinapic acid	530-59-6	224.2	C₁₁H₁₂O₅
CFN97787	Methyl sinapate	20733-94-2	238.24	C₁₂H₁₄O₅
CFN92506	3,4,5-Trimethoxy-trans-cinnamic acid	20329-98-0	238.2	C₁₂H₁₄O₅
CFN98182	3,4,5-Trimethoxycinnamic acid	90-50-6	238.24	C₁₂H₁₄O₅
CFN97691	Methyl 3,4,5-trimethoxycinnamate	7560-49-8	252.26	C₁₃H₁₆O₅
CFN98189	trans-2,3,4-Trimethoxycinnamic acid	33130-03-9	238.24	C₁₂H₁₄O₅
CFN97911	Secodihydro-hydramicromelin B	1212148-58-7	326.3	C₁₅H₁₈O₈