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Momordicoside A
Momordicoside A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Momordicoside A
Price:
CAS No.: 75801-95-5
Catalog No.: CFN93279
Molecular Formula: C42H72O15
Molecular Weight: 817.02 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Mormodica charantia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Momordicoside A has the inhibition effect on PIP1B.
In vitro:
Journal of Shaanxi Normal University,2008 ,36 (4) :63-67.
Isolation of the saponins from Momordica charantia and their PTP1B inhibition activity.[Reference: WebLink]
Five compounds were isolated from Momordica charantia L through the absorption of macroporous resin,silica gel column chromatography,reversed-phase silica gel column chromatography and detection of thin-layer chromatography(TLC).
METHODS AND RESULTS:
The structures of the compounds were characterized through the spectral technology including ESI-MS and NMR.They are α-spinasterol-3-Oβ-D-glucopyranoside(A),19(R)-carbonyl-25-dimethoxy-5β-5,19-epoxycucrbita-6,23-dien-3β-ol-3-Oβ-D-glucopyranoside(B),Momordicoside A(C),momordicoside L(D),and momordicoside K(E),respectively.The hypoglycemic activities of these five compounds were tested by using PTP1B(protein tyrosine phosphatase).
CONCLUSIONS:
The results indicated that the compounds D and E have not inhibition effect on PIP1B but the compound A,B and C have the inhibition effect.The sequence of inhibition activities is ACB.
Momordicoside A Description
Source: The herbs of Mormodica charantia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.224 mL 6.1198 mL 12.2396 mL 24.4792 mL 30.599 mL
5 mM 0.2448 mL 1.224 mL 2.4479 mL 4.8958 mL 6.1198 mL
10 mM 0.1224 mL 0.612 mL 1.224 mL 2.4479 mL 3.0599 mL
50 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.4896 mL 0.612 mL
100 mM 0.0122 mL 0.0612 mL 0.1224 mL 0.2448 mL 0.306 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhong Yao Cai. 1998 Sep;21(9):458-9.
Study on chemical components of Momordica charantia.[Pubmed: 12569838]

METHODS AND RESULTS:
The paper deals with the study of chemical constituents of the unmatured fruits of Chinese traditional medicine Momordica charantia L. which is usually used as green-stuff. There are two parts of the extracts obtained by ethanol precipitation, and four compounds obtained from the further isolation.
CONCLUSIONS:
They are identified as Vincine, Mycose, Momordicoside A and Momordicoside B.
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Ganoderic acid H

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Alisol B 23-acetate

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Petunidin-3-O-galactoside chloride

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Nimbolide

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trans-3-Hydroxycinnamic acid

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Sophoricoside

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