N-Methyltaxol C | CAS:153083-53-5 | Manufacturer ChemFaces

N-Methyltaxol C

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Description:

N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolated heart.

In vitro:

J Pharmacol Exp Ther. 1998 Feb;284(2):561-7.

Differential effects of paclitaxel and derivatives on guinea pig isolated heart and papillary muscle.[Pubmed: 9454798]

Paclitaxel (Taxol) is an anticancer agent with clinical activity against various human cancer types.
METHODS AND RESULTS:
Paclitaxel blocks cell division by stabilizing microtubules, a mechanism that also underlies its major side effects (neutropenia and neurotoxicity). Paclitaxel can also alter cardiac function, and to elucidate the mechanism of this activity, we tested the mechanical and electrical effects of paclitaxel and a series of analogs (docetaxel, taxol B, taxol C and N-Methyltaxol C; 5-20 microM) on two different cardiac preparations, the isolated coronary perfused heart and the papillary muscle of the guinea pig. Paclitaxel and N-Methyltaxol C induced conduction arrhythmias and reduced coronary flow and left ventricular systolic pressure in the isolated heart, whereas the other taxol derivatives tested had no significant effect. Moreover, paclitaxel blocked the vasodilator effect of bradykinin in the isolated heart. Paclitaxel and N-Methyltaxol C produced a positive inotropic effect in papillary muscle, without alterations in the action potential. In the latter preparation, no significant variations were observed after treatment with the other taxol derivatives.
CONCLUSIONS:
The in vitro cardiodepressant and arrhythmogenic activity of paclitaxel is similar to that reported after its clinical administration and might be due to coronary vasoconstriction. The precise role of microtubules as modulators of intracellular calcium in cardiac and smooth muscle cells is at present unclear, because docetaxel and other taxol analogs, though they exhibited similar activity on tubulin, lacked cardiac effects.

N-Methyltaxol C Description

Source:	The branches of Taxus Chinensis var.Mairei.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	N-Methyltaxol C
Price:
CAS No.:	153083-53-5
Catalog No.:	CFN89043
Molecular Formula:	C₄₇H₅₉NO₁₄
Molecular Weight:	861.97 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The branches of Taxus Chinensis var.Mairei.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cardiotoxicity Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1601 mL	5.8007 mL	11.6013 mL	23.2027 mL	29.0033 mL
5 mM	0.232 mL	1.1601 mL	2.3203 mL	4.6405 mL	5.8007 mL
10 mM	0.116 mL	0.5801 mL	1.1601 mL	2.3203 mL	2.9003 mL
50 mM	0.0232 mL	0.116 mL	0.232 mL	0.4641 mL	0.5801 mL
100 mM	0.0116 mL	0.058 mL	0.116 mL	0.232 mL	0.29 mL

CFN98517	Docetaxel	114977-28-5	807.88	C₄₃H₅₃NO₁₄
CFN98516	N-Debenzoyl-N-(tert-butoxycarbonyl)taxol	125354-16-7	849.92	C₄₅H₅₅NO₁₅
CFN98518	Cephalomannine	71610-00-9	831.91	C₄₅H₅₃NO₁₄
CFN90687	Deacetyltaxol	78432-77-6	811.87	C₄₅H₄₉NO₁₃
CFN90371	7-Epitaxol	105454-04-4	853.91	C₄₇H₅₁NO₁₄
CFN97759	Paclitaxel	33069-62-4	853.92	C₄₇H₅₁NO₁₄
CFN98515	7-Xylosyltaxol	90332-66-4	986.0	C₅₂H₅₉NO₁₈
CFN90837	10-Deacetyl-7-xylosyl paclitaxel	90332-63-1	944.0	C₅₀H₅₇NO₁₇
CFN89397	7-Epi-10-deacetyltaxol	78454-17-8	811.86	C₄₅H₄₉NO₁₃
CFN89395	7-Epi-10-deacetylcephalomannine	78479-12-6	789.86	C₄₃H₅₁NO₁₃