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Nardosinonediol
Nardosinonediol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Nardosinonediol
Price: $318 / 5mg
CAS No.: 20489-11-6
Catalog No.: CFN89546
Molecular Formula: C15H24O3
Molecular Weight: 252.34 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The herbs of Nardostachys jatamansi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $222.6 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Nardosinonediol shows cytotoxic activity against P-388 cells.
Nardosinonediol Description
Source: The herbs of Nardostachys jatamansi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9629 mL 19.8145 mL 39.6291 mL 79.2581 mL 99.0727 mL
5 mM 0.7926 mL 3.9629 mL 7.9258 mL 15.8516 mL 19.8145 mL
10 mM 0.3963 mL 1.9815 mL 3.9629 mL 7.9258 mL 9.9073 mL
50 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.5852 mL 1.9815 mL
100 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.7926 mL 0.9907 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4.
Cytotoxic sesquiterpenes from Nardostachys chinensis.[Pubmed: 8370115]

METHODS AND RESULTS:
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), Nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method.
CONCLUSIONS:
All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.
CFN89328Aristola-1(10),8-dien-2-one22391-34-0216.32C15H20O
CFN89419Debilon26808-51-5234.33C15H22O2
CFN95203Nardoaristolone B1422517-82-5218.3C14H18O2
CFN96977Kanshone A115356-18-8234.33C15H22O2
CFN89546Nardosinonediol20489-11-6252.34C15H24O3
CFN95180Isonardosinone27062-01-7264.3C15H20O4
CFN89522Narchinol B1356822-09-7208.25C12H16O3
CFN89358Desoxo-narchinol A53859-06-6192.25C12H16O2
CFN98699Nootkatone4674-50-4218.3 C15H22O
CFN95575Oxyphyllol B226546-99-2234.3C15H22O2
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