Neobyakangelicol | CAS:35214-82-5 | Manufacturer ChemFaces

Neobyakangelicol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $270.3 / In-stock
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Description:

Neobyakangelicol has anti-lipolytic hormones effects, it can strongly inhibit insulin- stimulated lipogenesis.

In vitro:

J Ethnopharmacol. 2004 Aug;93(2-3):243-6.

Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae.[Pubmed: 15234759 ]

METHODS AND RESULTS:
The methylene chloride extract of the root of Angelicae dahuricae showed high protective activity against 2,2'-azobis (2-aminodinopropane) dihydrochloride (AAPH)-induced cellular damage. From this extract, 11 furanocoumarins were isolated, namely oxypeucedanin hydrate, 9-hydroxy-4-methoxypsoralen, byakangelicin, pabulenol, alloisoimperatorin, Neobyakangelicol, byakangelicol, oxypeucedanin, imperatorin, phellotorin and isoimperatorin, respectively.
CONCLUSIONS:
Among these 11 furanocoumarins, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin displayed potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro.

Planta Med. 1982 Jul;45(3):183-7.

Effects of various coumarins from roots of Angelica dahurica on actions of adrenaline, ACTH and insulin in fat cells.[Reference: WebLink]

METHODS AND RESULTS:
Experiments were carried out on the effects of various coumarins on the actions of adrenaline, adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats. Furocoumarins such as oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin, phellopterin activated adrenaline-induced lipolysis. Furocoumarins such as oxypeucedanin hydrate, imperatorin and phellopterin also activated ACTH-induced lipolysis. On the other hand, furocoumarins such as byak-angelicin, Neobyakangelicol and isopimpinellin strongly inhibited insulin-stimulated lipogenesis.
CONCLUSIONS:
Therefore, the crude drug “Byakushi” may activate the actions of lipolytic hormones and selectively inhibit the effects of anti-lipolytic hormones.

Neobyakangelicol Description

Source:	The roots of Angelica dahurica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chem Pharm Bull (Tokyo). 1990 Apr;38(4):1084-6.

Studies on the antitumor-promoting activity of naturally occurring substances. II. Inhibition of tumor-promoter-enhanced phospholipid metabolism by umbelliferous materials.[Pubmed: 2379282 ]

METHODS AND RESULTS:
From the active fraction of the crude drug "Tang-Bai-Zhi," imperation (1), isoimperatoin (2), oxypeucedanin (3), pabulenol (4), Neobyakangelicol (5) and byakangelicin (6) were identified as active or inactive principles. Compound 4 had not previously been isolated from Tang-Bai-Zhi, A. dahurica var. pai-chi. We also discuss the structure-activity relationship among the above 6 kinds of linear-type furanocoumarins, together with 3 kinds of antitumor-promoter coumarins having the same skeleton, psoralen (7), bergapten (8) and xanthotoxin (9), obtained from "ashita-ba" (eaten as a vegetable in Japan).
CONCLUSIONS:
Among the compounds in the present experiment, compounds 1 and 2 showed potent inhibitory activity at the concentration of 50 micrograms/ml and 3-9 were found to have less or no activity.

Product Name	Neobyakangelicol
Price:	$318 / 5mg
CAS No.:	35214-82-5
Catalog No.:	CFN98462
Molecular Formula:	C₁₇H₁₆O₆
Molecular Weight:	316.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Angelica dahurica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-adipogenic Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1616 mL	15.8078 mL	31.6156 mL	63.2311 mL	79.0389 mL
5 mM	0.6323 mL	3.1616 mL	6.3231 mL	12.6462 mL	15.8078 mL
10 mM	0.3162 mL	1.5808 mL	3.1616 mL	6.3231 mL	7.9039 mL
50 mM	0.0632 mL	0.3162 mL	0.6323 mL	1.2646 mL	1.5808 mL
100 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.6323 mL	0.7904 mL

CFN95012	Alloisoimperatorin	35214-83-6	270.3	C₁₆H₁₄O₄
CFN93037	Alloimperatorin	642-05-7	270.28	C₁₆H₁₄O₄
CFN90495	Phellopterin	2543-94-4	300.3	C₁₇H₁₆O₅
CFN98167	Byakangelicol	26091-79-2	316.31	C₁₇H₁₆O₆
CFN98152	Byakangelicin	482-25-7	334.32	C₁₇H₁₈O₇
CFN98462	Neobyakangelicol	35214-82-5	316.3	C₁₇H₁₆O₆