Neostenine | CAS:477953-07-4 | Manufacturer ChemFaces

Neostenine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Neostenine shows significant antitussive activity.

In vivo:

Planta Med. 2003 Oct;69(10):914-20.

Antitussive activity of Stemona alkaloids from Stemona tuberosa.[Pubmed: 14648394]

METHODS AND RESULTS:
Bioactivity-directed fractionation of the crude extract of Stemona tuberosa led to the isolation and characterization of four new stenine-type Stemona alkaloids, namely tuberostemonine J ( 2), tuberostemonine H ( 3), epi-bisdehydrotuberostemonine J ( 4) and Neostenine ( 5), together with the known neotuberostemonine ( 1). These five isolated alkaloids were examined for antitussive activity in guinea pig after cough induction by citric acid aerosol stimulation.
CONCLUSIONS:
In this report, we demonstrated, for the first time, that compounds 1 and 5 showed significant antitussive activities. Further study of the structure-activity relationship on these isolated alkaloids and two synthetic analogues revealed that the saturated tricyclic pyrrolo[3,2,1- jk] benzazepine nucleus is the primary key structure contributing to the antitussive activity and all cis configurations at the three ring junctions are the optimal structure for the antitussive activity of stenine-type Stemona alkaloids.

Planta Med. 2006 Feb;72(3):211-6.

Intestinal absorption of Stemona alkaloids in a Caco-2 cell model.[Pubmed: 16534724]

METHODS AND RESULTS:
The intestinal absorption of neotuberostemonine and Neostenine, two major bioactive alkaloids of the commonly used antitussive traditional Chinese medicine Stemona tuberosa Lour, was investigated using a Caco-2 monolayer model. Both alkaloids exhibited a high absorptive permeability which was higher for Neostenine [P(app(AB)) = 12.03 +/- 1.14 x 10 (-6) cm/s] than for neotuberostemonine [P(app(AB)) = 9.27 +/- 0.79 x 10 (-6) cm/s], indicating that they are likely to be well absorbed and orally active. Furthermore, both alkaloids were identified to be the substrates of P-glycoprotein and have a transport preference from the basolateral to apical direction with efflux ratios between 2 and 3.
CONCLUSIONS:
Cyclosporin A dose-dependently inhibited the secretory permeability of these alkaloids and abolished their active efflux transport.

Neostenine Description

Source:	The roots of Stemona sessilifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Neostenine
Price:
CAS No.:	477953-07-4
Catalog No.:	CFN98725
Molecular Formula:	C₁₇H₂₇NO₂
Molecular Weight:	277.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Stemona sessilifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antitussive Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6049 mL	18.0245 mL	36.049 mL	72.0981 mL	90.1226 mL
5 mM	0.721 mL	3.6049 mL	7.2098 mL	14.4196 mL	18.0245 mL
10 mM	0.3605 mL	1.8025 mL	3.6049 mL	7.2098 mL	9.0123 mL
50 mM	0.0721 mL	0.3605 mL	0.721 mL	1.442 mL	1.8025 mL
100 mM	0.036 mL	0.1802 mL	0.3605 mL	0.721 mL	0.9012 mL

CFN98725	Neostenine	477953-07-4	277.4	C₁₇H₂₇NO₂
CFN97497	Sessilifoline A	929637-35-4	389.5	C₂₂H₃₁NO₅
CFN97534	Neotuberostemonone	954379-68-1	405.5	C₂₂H₃₁NO₆
CFN98138	Tuberostemonine	6879-01-2	375.51	C₂₂H₃₃NO₄
CFN99475	Neotuberostemonine	143120-46-1	375.5	C₂₂H₃₃NO₄
CFN96768	Bisdehydroneotuberostemonine	160333-27-7	371.47	C₂₂H₂₉NO₄
CFN80139	Protostemonine	27495-40-5	417.21	C₂₃H₃₁NO₆