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Norsanguinarine
Norsanguinarine
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Product Name Norsanguinarine
Price:
CAS No.: 522-30-5
Catalog No.: CFN92811
Molecular Formula: C19H11NO4
Molecular Weight: 317.1 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Chelidonium majus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Norsanguinarine has antifungal activity, it exhibits 100 % inhibition of A. brassicicola and C. maculans at 1000 ppm whereas. It shows significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.
Targets: Antifection
In vitro:
Folia Microbiol., 2009, 54(3):204-6.
Antifungal activity of the alkaloids from Eschscholtzia californica[Pubmed: 19649736 ]

METHODS AND RESULTS:
The isoquinoline alkaloids hunnemanine and Norsanguinarine have been isolated from methanolic extract of the whole plant of Eschscholzia californica. These two alkaloids were checked for their antifungal activity against phytopathogenic fungi Alternaria melongenae, A. brassicola, A. brassicae, Curvularia lunata, C. maculans, Helminthosporium pennisetti, H. oryzae, H. turcicum, Fusarium undum and F. lini.
CONCLUSIONS:
Hunnemanine exhibited 100 % inhibition of spore germination of A. brassicae, H. pennisetti and F. lini at 1000 ppm whereas Norsanguinarine exhibited 100 % inhibition of A. brassicicola and C. maculans at this concentration.
Norsanguinarine Description
Source: The herbs of Chelidonium majus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1536 mL 15.7679 mL 31.5358 mL 63.0716 mL 78.8395 mL
5 mM 0.6307 mL 3.1536 mL 6.3072 mL 12.6143 mL 15.7679 mL
10 mM 0.3154 mL 1.5768 mL 3.1536 mL 6.3072 mL 7.8839 mL
50 mM 0.0631 mL 0.3154 mL 0.6307 mL 1.2614 mL 1.5768 mL
100 mM 0.0315 mL 0.1577 mL 0.3154 mL 0.6307 mL 0.7884 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Molecular Structure.2004 Feb 3;689(1–2):115–120.
Theoretical and experimental NMR chemical shifts of norsanguinarine and norchelerythrine.[Reference: WebLink]

METHODS AND RESULTS:
Norchelerythrine and Norsanguinarine, tertiary benzo[c]phenanthridine alkaloids, were examined by gradient-selected 2D NMR spectroscopy and the later also by extensive theoretical calculations.
CFN98449Chelerythrine34316-15-9348.4 C21H18NO4
CFN95373Bocconoline32906-88-0379.4C22H21NO5
CFN993676-Acetonyl-N-methyl-dihydrodecarine1253740-09-8391.4 C23H21NO5
CFN982336-Acetonyldihydrochelerythrine22864-92-2405.5 C24H23NO5
CFN986088-Acetonyldihydrosanguinarine37687-34-6389.4 C23H19NO5
CFN923388-Acetonyldihydroavicine348098-59-9389.4C23H19NO5
CFN923398-Acetonyldihydronitidine80330-39-8405.5C24H23NO5
CFN91015bis[6-(5,6-dihydrochelerythrinyl)]amine165393-48-6711.76C42H37N3O8
CFN99749Acetylcorynoline18797-80-3409.43C23H23NO6
CFN90319Chelidonine476-32-4353.37C20H19NO5
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