Nyasicoside | CAS:111518-94-6 | Manufacturer ChemFaces

Nyasicoside

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Description:

Nyasicoside may have promising and beneficial thrombolytic activity.

In vitro:

J Basic Clin Physiol Pharmacol. 2016 Nov 1;27(6):659-66.

Antithrombotic and cytotoxic activities of four Bangladeshi plants and PASS prediction of their isolated compounds.[Pubmed: 27371821]

This study aims to investigate whether tested organic extracts possess antithrombotic properties with minimal or no toxicity and to predict the activity of some of their isolated compounds.
METHODS AND RESULTS:
An in vitro thrombolytic model was used to check the clot lysis effect of four Bangladeshi herbal extracts viz., roots ofCurculigo recurvataW.T. Aiton (Satipata), leaf ofAmorphophallus bulbiferRoxb. (Olkachu), leaf ofPhyllanthus sikkimensisMuell. Arg., and whole plant ofThunbergia grandifloraRoxb. (Nillata) using streptokinase as a positive control and water as a negative control. Cytotoxicity was screened by brine shrimp lethality bioassay using vincristine sulfate as positive control. In silico prediction of activity spectra for substances (PASS) prediction was applied for phytoconstituents, namely, Nyasicoside, glucomannan, grandifloric acid, serine, and alanine. Using an in vitro thrombolytic model,C. recurvata,A. bulbifer,P. sikkimensis, andT. grandiflorashowed 28.10±1.64%, 42.47±1.96%, 32.86±1.92%, and 25.51±1.67% of clot lysis, respectively. Reference drug streptokinase exhibited 75.00±3.04% clot lysis. Examined herbs showed significant (p<0.001) percentage (%) of clot lysis compared to negative control. In brine shrimp cytotoxic assay,C. recurvata,A. bulbifer,P. sikkimensis, andT. grandiflorashowed LC50values 210.64±3.44, 98.51±1.47, 187.29±2.01, and 386.43±3.02 μg/mL, respectively, with reference to vincristine sulfate (LC500.76±0.04). PASS predicted that examined phytoconstituents have a wide range of biological activity.
CONCLUSIONS:
Through our study it was found thatA. bulbiferandP. sikkimensiscould be considered as very promising and beneficial thrombolytic agents.

Nyasicoside Description

Source:	The herbs of Curculigo capitulata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 1999 May;62(5):734-9.

Three novel constituents from curculigo capitulata and revision of C-2 stereochemistry in nyasicoside.[Pubmed: 10346957]

METHODS AND RESULTS:
Continuing study of the constituents of the rhizomes of Curculigo capitulata provided three novel compounds, including two norlignan glucosides, curcapicycloside (2) and (1S,2R)-O-methylNyasicoside (3), and a phenanthrofuran, curcapital (9). The former two compounds were characterized as their tetra-O-methyl derivatives. Compound 2 possesses a glucosyl-fused skeleton with 1R,2R configuration. Biogenetic consideration led to a revision of the previously assigned 2S configuration of Nyasicoside (1) to 2R, which was confirmed by NOE studies of the acetonide of its tetra-O-methyl derivative. The 2R configuration in tetra-O-methyl-1-O-methyl curculigine (7a) and isocurculigine (8a) was also established by chemical correlation of the former with (1R, 2R)-tetra-O-methyl-1-O-methylNyasicoside (10a).
CONCLUSIONS:
Curcapital (9) represents the first natural product having a phenanthro[9,10, b]furan skeleton.

Product Name	Nyasicoside
Price:
CAS No.:	111518-94-6
Catalog No.:	CFN99212
Molecular Formula:	C₂₃H₂₆O₁₁
Molecular Weight:	478.5 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Curculigo capitulata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antithrombotic Compound Library Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0899 mL	10.4493 mL	20.8986 mL	41.7973 mL	52.2466 mL
5 mM	0.418 mL	2.0899 mL	4.1797 mL	8.3595 mL	10.4493 mL
10 mM	0.209 mL	1.0449 mL	2.0899 mL	4.1797 mL	5.2247 mL
50 mM	0.0418 mL	0.209 mL	0.418 mL	0.8359 mL	1.0449 mL
100 mM	0.0209 mL	0.1045 mL	0.209 mL	0.418 mL	0.5225 mL

CFN95110	Pilosidine	229971-57-7	478.5	C₂₃H₂₆O₁₁
CFN95879	4-(3,5-Dihydroxy-7-(4-hydroxy-3-methoxyphenyl)heptyl)benzene-1,2-diol	884495-94-7	362.4	C₂₀H₂₆O₆
CFN90584	Octahydrocurcumin	36062-07-4	376.44	C₂₁H₂₈O₆
CFN95880	5'-Hydroxyoctahydrocurcumin	N/A	392.5	C₂₁H₂₈O₇
CFN95861	5'-Methoxyoctahydrocurcumin	718638-77-8	406.5	C₂₂H₃₀O₇
CFN97749	Hexahydrocurcumin	36062-05-2	374.43	C₂₁H₂₆O₆
CFN90583	Tetrahydrocurcumin	36062-04-1	372.41	C₂₁H₂₄O₆
CFN99185	Demethoxycurcumin	22608-11-3	338.35	C₂₀H₁₈O₅
CFN99186	Bisdemethoxycurcumin	33171-05-0	308.33	C₁₉H₁₆O₄
CFN98686	Curcumin	458-37-7	368.4	C₂₁H₂₀O₆