Science | Nature | Cell | View More
Natural Products
Ginkgolic acid C13:0
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ginkgolic acid C13:0
Price: $168 / 20mg
CAS No.: 20261-38-5
Catalog No.: CFN98507
Molecular Formula: C20H32O3
Molecular Weight: 320.47 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The leaves of Ginkgo biloba L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $32.3 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Kyung Hee University (Korea)
  • The University of Newcastle (Australia)
  • Northeast Normal University Cha... (China)
  • University of Medicine and Phar... (Romania)
  • Texas A&M University (USA)
  • Kazusa DNA Research Institute (Japan)
  • The Australian National University (Australia)
  • Monash University Sunway Campus (Malaysia)
  • Shanghai Institute of Biochemis... (China)
  • Universidade da Beira Interior (Germany)
  • Hamdard University (India)
  • More...
Package
Featured Products
Oleanolic acid

Catalog No: CFN98800
CAS No: 508-02-1
Price: $30/20mg
Ginsenoside Rh3

Catalog No: CFN99972
CAS No: 105558-26-7
Price: $218/5mg
Shionone

Catalog No: CFN99784
CAS No: 10376-48-4
Price: $60/20mg
Inokosterone

Catalog No: CFN92515
CAS No: 15130-85-5
Price: $ / mg
3'-Demethylnobiletin

Catalog No: CFN93130
CAS No: 112448-39-2
Price: $188/10mg
Pilloin

Catalog No: CFN96503
CAS No: 32174-62-2
Price: $218/10mg
Geraniin

Catalog No: CFN90256
CAS No: 60976-49-0
Price: $100/20mg
Withaferin A

Catalog No: CFN91895
CAS No: 5119-48-2
Price: $298/20mg
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
Gymnemic acid I

Catalog No: CFN90538
CAS No: 122168-40-5
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ginkgolic acid C13:0 has a wide antimicrobial spectrum against E.coli and bacillus subtilis who are bacterias, and penicillium, penicillum purpurogenum, penicillium camemberti and aspergillus niger who are fungis, and the MIC of it against E.coli, bacillus subtilis and penicillium is 7.5, 15, 25 mg/mL seperately. It is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgolic acid C13:0 exhibits the high α-glucosidase inhibitory activity; Ginkgolic acid C13:0 represents a new kind of molluscicide agent , it has a pronounced effect on snail mitochondria with gross ultrastructural changes.
Targets: Antifection | α-glucosidase
In vitro:
Journal of Chinese Institute of Food Science and Technology. 2015, 15(3):207-15.
Purification, identification and the antimicrobial activity of ginkgolic acids in ginkgo seeds.[Reference: WebLink]
Ginkgo seeds were used as materials in this experiment, Ginkgolic acids in ginkgo seeds were extracted by ethanol, and the ethanol extract were further extracted with petroleum ether.
METHODS AND RESULTS:
The purification process of the ginkgolic acids were studied, and the compositions and contents were analyzed and detected by the methods of combination of HPLC and LC-MS. And two bacterias and four fungis were used for tested strains, the antimicrobial activity of ginkgolic acids were tested and the minimal inhibitory concentration (MIC) were determined separately. The results show that taking 89:1:11 system of petroleum ether, ethyl ether, and methanol as eluents, at 1.2 mL/min velocity, the effect of the silica gel column chromatography purification is the better. HPLC and LC -MS analysis showed that ginkgolic acids in ginkgo seeds consists chiefly of Ginkgolic acid C13:0, C15:1, C17:2, C15:0, C17:1. The content of ginkgolic acids in skimmed ginkgo powder is 0.11 g/kg by the C13:0, C15:1, C17:1 and the content of Ginkgolic acid C13:0, C15:1, C17:1 is 0.013, 0.042, 0.055 g/kg separately.
CONCLUSIONS:
The antimicrobial tests showed that ginkgolic acids had a wide antimicrobial spectrum against E.coli and bacillus subtilis who are bacterias, and penicillium, penicillum purpurogenum, penicillium camemberti and aspergillus niger who are fungis. And the MIC of the ginkgolic acids against E.coli, bacillus subtilis and penicillium is 7.5, 15, 25 mg/mL seperately.
In vivo:
Aquaculture, 2009, 297(1-4):38-43.
In vivo assessment of anthelmintic efficacy of ginkgolic acids (C13:0, C15:1) on removal of Pseudodactylogyrus in European eel[Reference: WebLink]
Pseudodactylogyrus is a significant monogenean parasite of the gills of aquacultured European eels, and can cause severe gill pathology. In this study, effects of the crude extracts, fractions and compounds of exopleura of Ginkgo biloba against Pseudodactylogyrus were investigated under in vivo conditions by bio-assay guided isolation method.
METHODS AND RESULTS:
Four solvents (petroleum ether, ethyl acetate, n-butanol and water) were applied for the extraction of exopleura of G. biloba. Among them, only the petroleum ether extract showed strong activity and therefore, subjected to further separation and purification using various chromatographic techniques. Two compounds showing potent activity were identified by comparing spectral data (IR, NMR, and EI-MS) with literature values to be Ginkgolic acid C13:0 and C15:1. They were found to be 100% effective at the concentration of 2.5 mg l- 1 and 6.0 mg l- 1, with ED50 values of 0.72 mg l- 1 and 2.88 mg l- 1, respectively. In the 5-days safety test, Ginkgolic acid C13:0 and C15:1 were shown to be safe for healthy juvenile eels when the concentration were up to 10.0 and 18.0 mg l- 1, respectively.
CONCLUSIONS:
The two compounds exhibited potential results and can be explored as plant-derived antiparasitic for the control of Pseudodactylogyrus.
Ginkgolic acid C13:0 Description
Source: The leaves of Ginkgo biloba L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Torosachrysone 8-O-beta-gentiobios...

Catalog No: CFN95131
CAS No: 94356-13-5
Price: $318/5mg
Dihydrophaseic acid 4'-O-beta-D-gl...

Catalog No: CFN95393
CAS No: 78914-56-4
Price: $318/5mg
Arisantetralone B

Catalog No: CFN95211
CAS No: 1161947-96-1
Price: $413/5mg
Ganoderic acid GS-2

Catalog No: CFN95549
CAS No: 1206781-65-8
Price: $413/5mg
Cannabisin A

Catalog No: CFN95287
CAS No: 130508-46-2
Price: $318/5mg
5-Demethylsinensetin

Catalog No: CFN95415
CAS No: 21763-80-4
Price: $318/10mg
3-Hydroxymollugin

Catalog No: CFN95424
CAS No: 154706-45-3
Price: $368/5mg
New compound 17

Catalog No: CFN95466
CAS No: N/A
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1204 mL 15.6021 mL 31.2042 mL 62.4083 mL 78.0104 mL
5 mM 0.6241 mL 3.1204 mL 6.2408 mL 12.4817 mL 15.6021 mL
10 mM 0.312 mL 1.5602 mL 3.1204 mL 6.2408 mL 7.801 mL
50 mM 0.0624 mL 0.312 mL 0.6241 mL 1.2482 mL 1.5602 mL
100 mM 0.0312 mL 0.156 mL 0.312 mL 0.6241 mL 0.7801 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Pak J Biol Sci. 2014 Nov;17(11):1170-8.
Potent α-glucosidase inhibitors isolated from Ginkgo biloba leaves.[Pubmed: 26027162]
In vitro α-glucosidase inhibitory activity of Ginkgo biloba leaves was investigated.
METHODS AND RESULTS:
The inhibitory activity of methanol extracts from yellow and green leaves was 13.8 and 40.1 μg mL(-1), respectively. Each methanol extract was separated into its respective fraction by solvent-solvent extraction with n-hexane, chloroform, ethyl acetate and n-butanol. The n-hexane fractions (in both methanol extracts from green and yellow leaves) exhibited high α-glucosidase inhibitory activity with IC50 values of 13.6 and 13.4 μg mL(-1), respectively. Further fractionation of the n-hexane fractions by silica gel column chromatography gave the most active fraction which was identified as Ginkgolic acid C13:0 and a mixture (C13:0, C15:0, C15: 1, C17:1 and C17:2). Ginkgolic acid C13:0 exhibited the highest α-glucosidase inhibitory activity.
CONCLUSIONS:
This is the first study to successfully isolate ginkgolic acids as α-glucosidase inhibitors.
Animal Research:
Pestic. Biochem. Phys., 2012, 103(2):115-20.
Effects of the molluscicidal agent GA-C13:0, a natural occurring ginkgolic acid, on snail mitochondria.[Reference: WebLink]
Ginkgolic acids (GAs) from the leaves and sarcotesta of Ginkgo biloba L. represent a new kind of molluscicide agent. To date, the mechanism(s) for the observed molluscicidal activity remains largely unknown. Since Ginkgolic acid C13:0(GA-C13:0) has effectively inhibited snail mobility, we examined the effects of the compound on mitochondrial function and gene expression as compared to niclosamide.
METHODS AND RESULTS:
Snail mitochondrial damage induced by GAs was tested using transmission electron microscopy (TEM) and gene-expression profiling of five mitochondrial enzymes using real-time PCR. GA-C13:0 was found to have a pronounced effect on snail mitochondria with gross ultrastructural changes. In addition, GA-C13:0 was also found to inhibit the gene expression of four mitochondrial enzymes including cytochrome c oxidase, adenosine triphosphate (ATP) synthase, cytochrome b and dihydronicotinamide adenine dinucleotide (NADH) dehydrogenase. In contrast, niclosamide did not show such effects on mitochondrial function and gene expression, suggesting that the molluscicidal activity of GA-C13:0 and niclosamide differed.
CONCLUSIONS:
Our results imply that snail mitochondria are a potential target for the molluscicidal activity of ginkgolic acids.
Oleanolic acid

Catalog No: CFN98800
CAS No: 508-02-1
Price: $30/20mg
Ginsenoside Rh3

Catalog No: CFN99972
CAS No: 105558-26-7
Price: $218/5mg
Shionone

Catalog No: CFN99784
CAS No: 10376-48-4
Price: $60/20mg
Inokosterone

Catalog No: CFN92515
CAS No: 15130-85-5
Price: $ / mg
3'-Demethylnobiletin

Catalog No: CFN93130
CAS No: 112448-39-2
Price: $188/10mg
Pilloin

Catalog No: CFN96503
CAS No: 32174-62-2
Price: $218/10mg
Geraniin

Catalog No: CFN90256
CAS No: 60976-49-0
Price: $100/20mg
Withaferin A

Catalog No: CFN91895
CAS No: 5119-48-2
Price: $298/20mg
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
Gymnemic acid I

Catalog No: CFN90538
CAS No: 122168-40-5
Price: $ / mg
Tags: buy Ginkgolic acid C13:0 | Ginkgolic acid C13:0 supplier | purchase Ginkgolic acid C13:0 | Ginkgolic acid C13:0 cost | Ginkgolic acid C13:0 manufacturer | order Ginkgolic acid C13:0 | Ginkgolic acid C13:0 distributor