Odorinol | CAS:72755-22-7 | Manufacturer ChemFaces

Odorinol

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Description:

Odorine and odorinol inhibit both the initiation and promotion stages of two-stage skin carcinogenesis. (+)-Odorinol exhibits strong antiviral activity against Ranikhet disease virus (RVD) in chick embryo.

Targets:

Antifection | NO

In vitro:

Biol Pharm Bull. 2001 Nov;24(11):1282-5.

Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.[Pubmed: 11725964]

METHODS AND RESULTS:
In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and Odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter.
CONCLUSIONS:
From these results, it was concluded that odorine and Odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.

Planta Medica, 1987 , 53 (3) :254-5.

Antiviral activity of (+)-odorinol.[Reference: WebLink]

METHODS AND RESULTS:
A phytochemical investigation of AGLAIA ROXBURGHIANA var. Beddomei (Meliaceae) resulted in the isolation of the active principle and its characterisation as (+)-Odorinol exhibiting strong antiviral activity against Ranikhet disease virus (RVD) in chick embryo.

Odorinol Description

Source:	The herbs of Aglaia odorata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Odorinol
Price:
CAS No.:	72755-22-7
Catalog No.:	CFN97211
Molecular Formula:	C₁₈H₂₄N₂O₃
Molecular Weight:	316.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Aglaia odorata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Cancer chemoprevention Compound Library Alkaloids Compound Library NO Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1606 mL	15.8028 mL	31.6056 mL	63.2111 mL	79.0139 mL
5 mM	0.6321 mL	3.1606 mL	6.3211 mL	12.6422 mL	15.8028 mL
10 mM	0.3161 mL	1.5803 mL	3.1606 mL	6.3211 mL	7.9014 mL
50 mM	0.0632 mL	0.3161 mL	0.6321 mL	1.2642 mL	1.5803 mL
100 mM	0.0316 mL	0.158 mL	0.3161 mL	0.6321 mL	0.7901 mL

CFN91684	Palvanil	69693-13-6	391.6	C₂₄H₄₁NO₃
CFN90241	Nordihydrocapsaicin	28789-35-7	293.40	C₁₇H₂₇NO₃
CFN99917	Capsaicin	404-86-4	305.42	C₁₈H₂₇NO₃
CFN99918	Dihydrocapsaicin	19408-84-5	307.43	C₁₈H₂₉NO₃
CFN90964	Homodihydrocapsaicin I	20279-06-5	321.45	C₁₉H₃₁NO₃
CFN91410	Dihydrohomocapsaicin II	71239-21-9	321.5	C₁₉H₃₁NO₃
CFN99529	Leonurine hydrochloride	24735-18-0	347.8	C₁₄H₂₁O₅N₃.HCl
CFN97210	Odorine	72755-20-5	300.4	C₁₈H₂₄N₂O₂
CFN97211	Odorinol	72755-22-7	316.4	C₁₈H₂₄N₂O₃
CFN90843	Macamide B	74058-71-2	345.6	C₂₃H₃₉NO