Officinalisinin I | CAS:57944-18-0 | Manufacturer ChemFaces

Officinalisinin I

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Size /Price /Stock	10 mM * 1 mL in DMSO / $161.2 / In-stock
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Description:

Officinalisinin Ⅰcan effectively reduce the blood glucose and protect nerve injuryin diabetic mice.

In vivo:

China Journal of Traditional Chinese Medicine & Pharmacy, 2017 (2) :782-785.

Study on hypoglycemic mechanism and central nerve protection of Officinalisinin Ⅰ in Rhizoma Anemarrhenae[Reference: WebLink]

To study the hypoglycemic effect of Officinalisinin Ⅰin Rhizoma Anemarrhenae on diabetes, and discuss the hypoglycemic mechanism and protective effect on diabetic nephropathy.
METHODS AND RESULTS:
Glucose tolerance was measured in model mice induced by oral administration of alloxan.Inhibition of glycosidase activity was tested in vitro.GLP-1 was detected after fasting in diabetic mice.The levels of BDNF and GSH-PX in serum were detected by enzyme-linked immunosorbent assay(ELISA) after 20 days of medication.Officinalisinin I has the functions of lowering blood glucose and significantly improving the glucose tolerance of diabetic mice.In the experiment, the glycosidase inhibitor pathway was eliminated, andby promoting the generation of GLP-1 and BDNF and increasing the activity of GSH-PX Officinalisinin I achieves the hypoglycemic and neuroprotective effect.
CONCLUSIONS:
Officinalisinin I can effectively reduce the blood glucose and protect nerve injuryin diabetic mice.

Officinalisinin I Description

Source:	The rhizomes of Anemarrhena asphodeloides Bunge
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Officinalisinin I
Price:	$248 / 20mg
CAS No.:	57944-18-0
Catalog No.:	CFN90692
Molecular Formula:	C₄₅H₇₆O₁₉
Molecular Weight:	921.07 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The rhizomes of Anemarrhena asphodeloides Bunge
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Antihyperglycemic Compound Library Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0857 mL	5.4285 mL	10.8569 mL	21.7139 mL	27.1423 mL
5 mM	0.2171 mL	1.0857 mL	2.1714 mL	4.3428 mL	5.4285 mL
10 mM	0.1086 mL	0.5428 mL	1.0857 mL	2.1714 mL	2.7142 mL
50 mM	0.0217 mL	0.1086 mL	0.2171 mL	0.4343 mL	0.5428 mL
100 mM	0.0109 mL	0.0543 mL	0.1086 mL	0.2171 mL	0.2714 mL

CFN90692	Officinalisinin I	57944-18-0	921.07	C₄₅H₇₆O₁₉
CFN99533	Anemarsaponin E	136565-73-6	934.03	C₄₆H₇₈O₁₉
CFN95321	(3beta,22alpha)-26-(beta-glucopyranosyloxy)-22-methoxyfurost-5-en-3-yl 2-O-(6-deoxy-alpha-mannopyranosyl)-beta-glucopyranosiduronic acid	107783-53-9	931.1	C₄₆H₇₄O₁₉
CFN99517	Protodioscin	55056-80-9	1049.21	C₅₁H₈₄O₂₂
CFN99585	Methyl protodioscin	54522-52-0	1063.23	C₅₂H₈₆O₂₂
CFN93008	Protodeltonin	94992-08-2	1065.21	C₅₁H₈₄O₂₃
CFN93038	Pseudoprotogracillin	637349-03-2	1047.2	C₅₁H₈₂O₂₂
CFN93054	Protogracillin	54848-30-5	1065.21	C₅₁H₈₄O₂₃
CFN80084	Methyl protogracillin	54522-53-1	1078.55	C₅₂H₈₆O₂₃
CFN99955	Polyphyllin G	76296-75-8	1049.22	C₅₁H₈₄O₂₂