Pluviatolide | CAS:28115-68-6 | Manufacturer ChemFaces

Pluviatolide

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Description:

(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.

Targets:

AChR

In vitro:

J Nat Prod. 2008 Jul;71(7):1167-72.

Chemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.[Pubmed: 18570470 ]

Twenty constituents were isolated from the n-hexane and chloroform extracts of Aristolochia constricta, a plant whose aerial parts have been used empirically in folk medicine for various purposes.
METHODS AND RESULTS:
The inhibitory effects of these constituents on smooth muscle contraction in isolated guinea-pig ileum were studied in order to observe their antispasmodic effects. 3,4-Dibenzyldihydrofuran-type lignans [(-)-cubebin, (-)-hinokinin, and (-)-Pluviatolide] and a kaurene-type diterpene [(-)-kaur-16-en-19-oic acid] were isolated as active principals. They inhibited electrically induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. In addition, 9- O-[(-)-kaur-15-en-17-oxyl]cubebin was isolated as a new diterpeno-lignan hybrid, although this constituent did not exhibit antispasmodic activity.

Pluviatolide Description

Source:	The herbs of Macaranga tanarius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Pluviatolide
Price:
CAS No.:	28115-68-6
Catalog No.:	CFN92059
Molecular Formula:	C₂₀H₂₀O₆
Molecular Weight:	356.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Macaranga tanarius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-spasmodic Compound Library Lignans Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8058 mL	14.0292 mL	28.0584 mL	56.1167 mL	70.1459 mL
5 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
10 mM	0.2806 mL	1.4029 mL	2.8058 mL	5.6117 mL	7.0146 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.5612 mL	0.7015 mL

CFN95008	Isonemerosin	181524-79-8	398.4	C₂₂H₂₂O₇
CFN97895	2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide	137809-97-3	352.3	C₂₀H₁₆O₆
CFN99396	7-Oxohinokinin	130837-92-2	368.3	C₂₀H₁₆O₇
CFN95243	Neoarctin B	155969-67-8	742.8	C₄₂H₄₆O₁₂
CFN96251	Bis-5,5-nortrachelogenin	870480-56-1	746.8	C₄₀H₄₂O₁₄
CFN95067	Lappaol A	62333-08-8	536.6	C₃₀H₃₂O₉
CFN95224	Isolappaol A	131400-96-9	536.6	C₃₀H₃₂O₉
CFN95242	Lappaol B	62359-60-8	550.6	C₃₁H₃₄O₉
CFN95068	Lappaol C	64855-00-1	554.6	C₃₀H₃₄O₁₀
CFN95225	Isolappaol C	929905-15-7	554.6	C₃₀H₃₄O₁₀