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Podophyllotoxinone
Podophyllotoxinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Podophyllotoxinone
Price:
CAS No.: 477-49-6
Catalog No.: CFN91909
Molecular Formula: C22H20O8
Molecular Weight: 412.39 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Dysosma versipellis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Podophyllotoxinone shows inhibitory activity against L1210 leukemia and KB cells in vitro.
Podophyllotoxinone Description
Source: The herbs of Dysosma versipellis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4249 mL 12.1244 mL 24.2489 mL 48.4978 mL 60.6222 mL
5 mM 0.485 mL 2.4249 mL 4.8498 mL 9.6996 mL 12.1244 mL
10 mM 0.2425 mL 1.2124 mL 2.4249 mL 4.8498 mL 6.0622 mL
50 mM 0.0485 mL 0.2425 mL 0.485 mL 0.97 mL 1.2124 mL
100 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.485 mL 0.6062 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese Journal of Pharmaceuticals, 1993.
SYNTHESIS AND ANTITUMOR ACTIVITY OF PODOPHYLLOTOXINONE AND ITS HYDROXYIMINO ANALOGUES[Reference: WebLink]

METHODS AND RESULTS:
Podophyllotoxinone and its hydroxyimino analogues have been synthesized by oxidation and oximation.
CONCLUSIONS:
The results of their inhibitory activities against L1210 leukemia and KB cells in vitro indicated that they were generally weaker than that of etoposide.
CFN95705Justicidin D(Neojusticin A)27041-98-1378.3C21H14O7
CFN95174Marginatoxin1422536-56-8398.4C22H22O7
CFN97279gamma-Diasarone80434-33-9416.5 C24H32O6
CFN97420alpha-Conidendrin85699-62-3356.4 C20H20O6
CFN92623Isoanthricin17301-70-5398.4C22H22O7
CFN70412alpha-Peltatin568-53-6400.4C21H20O8
CFN92699(-)-beta-Peltatin518-29-6414.4C22H22O8
CFN92700(-)-beta-Peltatin-5-O-beta-D-glucopyranoside11024-59-2576.6C28H32O13
CFN99888Deoxypodophyllotoxin19186-35-7398.4 C22H22O7
CFN904834'-Demethylpodophyllotoxin40505-27-9400.37C21H20O8
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