1-Caffeoylquinic acid | CAS:1241-87-8 | Manufacturer ChemFaces

1-Caffeoylquinic acid

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

Biotech R&D Institute (USA)
University of Hertfordshire (United Kingdom)
University of Medicine and Phar... (Romania)
Complutense University of Madrid (Spain)

Julius Kühn-Institut (Germany)
University of Beira Interior (Portugal)
Aarhus University (Denmark)
University of Vienna (Austria)

University of Queensland (Australia)
Periyar University (India)
Instituto de Investigaciones Ag... (Chile)
More...

Package

Featured Products

More...

Magnolol

Catalog No: CFN98872
CAS No: 528-43-8
Price: $30/20mg

Praeruptorin A

Catalog No: CFN98139
CAS No: 73069-25-7
Price: $60/20mg

Sanguinarine

Catalog No: CFN98259
CAS No: 2447-54-3
Price: $30/20mg

Isovitexin

Catalog No: CFN98620
CAS No: 38953-85-4
Price: $50/20mg

Calceolarioside A

Catalog No: CFN98522
CAS No: 84744-28-5
Price: $ /

Palmatine

Catalog No: CFN98459
CAS No: 3486-67-7
Price: $40/20mg

Dicentrine

Catalog No: CFN92331
CAS No: 517-66-8
Price: $ / mg

Sweroside

Catalog No: CFN99455
CAS No: 14215-86-2
Price: $40/20mg

Mesaconitine

Catalog No: CFN99199
CAS No: 2752-64-9
Price: $98/20mg

Pimaric acid

Catalog No: CFN99382
CAS No: 127-27-5
Price: $ /

Description:

1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows the release of glucose into the bloodstream after a meal.

Targets:

NF-kB

In vitro:

J Agric Food Chem. 2013 Nov 6;61(44):10507-15.

Qualitative and quantitative analysis of phenolics in Tetrastigma hemsleyanum and their antioxidant and antiproliferative activities.[Pubmed: 24151872]

The phenolic profiles of Tetrastigma hemsleyanum leaf extracts by different solvents (80% methanol, ethyl acetate and hexane) and their antioxidant and antiproliferative activities were investigated.
METHODS AND RESULTS:
Thirteen phenolic compounds (3-caffeoylquinic acid, 5-caffeoylquinic acid, 1-Caffeoylquinic acid, 5-p-coumaroylquinic acid, isoorientin-2″-O-rhamnoside, isoorientin, orientin-2″-O-rhamnoside, orientin, 1-p-coumaroylquinic acid, vitexin-2″-O-rhamnoside, isovitexin-2″-O-rhamnoside, vitexin and isovitexin) were identified in T. hemsleyanum leaves for the first time, and six of them were quantified using a combination of LC-QTOF-MS and LC-QqQ-MS techniques. It was found that 80% methanol extract exhibited the highest antioxidant activities.
CONCLUSIONS:
This paper provides a complete picture of phenolics in T. hemsleyanum leaves and relates them to their antioxidant and antiproliferative activities.

Anal Biochem . 2018 Apr 15;547:52-56.

PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy[Pubmed: 29428377]

Abstract Following the FDA approval of three monoclonal antibodies of PD-1/PD-L1, this pathway has become a promising target for cancer treatment. Currently small-molecule inhibitors have not been extensively investigated, and appropriate screening methods for such inhibitors are urgently required. In this study, surface plasmon resonance (SPR) technology was used to evaluate the affinity and competitive inhibition of nine caffeoylquinic acid compounds (CQAs) against PD-1/PD-L1. As a result, four small molecules including 1-CQA, 3-CQA, 4-CQA and 5-CQA were determined as PD-1/PD-L1 inhibitors. This study provided an efficient method for screening small-molecule inhibitors targeting PD-1/PD-L1 pathway. Keywords: Caffeoylquinic acid compounds; PD-1; PD-L1; Small-molecule inhibitors; Surface plasmon resonance.

In vivo:

BMC Complement Altern Med . 2017 Jun 17;17(1):320.

Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model[Pubmed: 28623927]

Abstract Background: The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. Methods: G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model. Results: G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia. The extract of G. pensylvanicum also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, 13 caffeoylquinic acid derivatives and 1 flavone were identified by UPLC-ESI-MS/MS as the main active component of G. pensylvanicum. Conclusions: The extract of G. pensylvanicum showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis. Keywords: Acute gouty arthritis; Caffeoylquinic acid derivatives; Gnaphalium pensylvanicum Willd.; Hyperuricemia; Pro-inflammatory cytokines; Xanthine oxidase.

1-Caffeoylquinic acid Description

Source:	The herb of Lonicera japonica Thunb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Pharmacogn Mag. 2013 Jan;9(33):51-7.

Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.[Pubmed: 23661994]

Dietary phytochemicals consist of a wide variety of biologically active compounds that are ubiquitous in plants, many of which have been reported to have anti-tumor as well as anti-inflammatory properties. In the present study, we aimed to validate these findings by using docking protocols and explicate the possible mechanism of action for a dataset of nine phytochemicals namely boswellic acid, 1-Caffeoylquinic acid, ellagic acid, emodin, genistein, guggulsterone, quercetin, resveratrol, and sylibinin from different plants against the nuclear factor- kappaB (NF-κB) precursor protein p105, an important transcription factor reported to be overexpressed in breast cancer.
METHODS AND RESULTS:
2-D structures of all phytochemicals were retrieved from PubChem Compound database and their subsequent conversion into 3-D structures was performed by using online software system CORINA. The X-ray crystallographic structure of the NF-κB precursor p105 was extracted from Brookhaven Protein Data Bank. Molecular docking simulation study was carried out by using AutoDock Tools 4.0. Our results showed significant binding affinity of different phytochemicals with the Rel homology domain of the NF-κB precursor protein p105. Quercetin and 1-Caffeoylquinic acid were found to be very effective inhibitors against target molecule as they showed binding energy of -12.11 and -11.50 Kcal/mol, respectively. The order of affinity of other ligands with p105 was found as follows: guggulsterone > sylibinin > emodin > resveratrol > genistein > boswellic acid > ellagic acid.
CONCLUSIONS:
Our in silico study has explored the possible chemopreventive mechanism of these phytochemicals against the NF-κB precursor protein p105 and deciphered that quercetin, 1-Caffeoylquinic acid and guggulsterone were the potent inhibitors against target molecule. In addition, large scale preclinical and clinical trials are needed to explore the role of these chemotherapeutic molecules against the NF-κB precursor protein p105 in cure and prevention of breast cancer.

Product Name	1-Caffeoylquinic acid
Price:	$350 / 10mg
CAS No.:	1241-87-8
Catalog No.:	CFN99121
Molecular Formula:	C₁₆H₁₈O₉
Molecular Weight:	354.31 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	White powder
Source:	The herb of Lonicera japonica Thunb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Phenylpropanoids Compound Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8224 mL	14.1119 mL	28.2239 mL	56.4477 mL	70.5597 mL
5 mM	0.5645 mL	2.8224 mL	5.6448 mL	11.2895 mL	14.1119 mL
10 mM	0.2822 mL	1.4112 mL	2.8224 mL	5.6448 mL	7.056 mL
50 mM	0.0564 mL	0.2822 mL	0.5645 mL	1.129 mL	1.4112 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.5645 mL	0.7056 mL

CFN92573	3-O-Caffeoylquinic acid methyl ester	123483-19-2	368.3	C₁₇H₂₀O₉
CFN91565	Ethyl chlorogenate	425408-42-0	382.4	C₁₈H₂₂O₉
CFN92393	3-O-Feruloylquinic acid	1899-29-2	368.3	C₁₇H₂₀O₉
CFN95731	cis-3-O-Feruloylquinic acid	89886-27-1	368.3	C₁₇H₂₀O₉
CFN92446	Methyl 3-O-feruloylquinate	154418-15-2	382.4	C₁₈H₂₂O₉
CFN92529	Cyclohexanecarboxylic acid	327161-03-5	354.3	C₁₆H₁₈O₉
CFN95508	4-O-Coumaroylquinic acid	53539-37-0	338.1	C₁₆H₁₈O₈
CFN99117	Cryptochlorogenic acid	905-99-7	354.31	C₁₆H₁₈O₉
CFN92528	Methyl 4-caffeoylquinate	123372-74-7	368.3	C₁₇H₂₀O₉
CFN92392	4-O-Feruloylquinic acid	2613-86-7	368.3	C₁₇H₂₀O₉