Polygalic acid | CAS:1260-04-4 | Manufacturer ChemFaces

Polygalic acid

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Size /Price /Stock	10 mM * 1 mL in DMSO / $33.8 / In-stock
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Description:

Polygalic acid, a triterpenoid saponin, shows expectorant, emetic and stimulant effects.

In vivo:

Biomed Chromatogr. 2012 Feb;26(2):220-4.

In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn.[Pubmed: 21618563 ]

A very simple and direct method has been established for the determination of Polygalic acid and its metabolites in rat urine based on HPLC coupled with electrospray ionization multi-stage tandem mass spectrometry (HPLC-ESI-MS(n)).
METHODS AND RESULTS:
The rats were administered a single dose (100 mg/kg) of Polygalic acid by oral gavage. The urine samples were collected and purified through a C(18) solid-phase extraction cartridge, and then these pretreated samples were injected into a reversed-phase C(18) column with a gradient elution program, whereas acetonitrile-0.5% aqueous formic acid was used as mobile phase and detected by an on-line MS/MS system. As a result, the parent drug and its four metabolites were identified and characterized in rat urine for the first time by comparing their changes in molecular mass (ΔM), retention times and full-scan MS(n) spectra with those of the parent drug. A possible metabolic pathway of Polygalic acid was investigated and proposed.
CONCLUSIONS:
More importantly, the results demonstrated that the newly developed method (HPLC-ESI-MS(n)) was sensitive, simple and suitable for the determination of Polygalic acid and its metabolites in biological samples.

Polygalic acid Description

Source:	The roots of Polygala tenuifolia Willd
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Polygalic acid
Price:	$138 / 20mg
CAS No.:	1260-04-4
Catalog No.:	CFN92195
Molecular Formula:	C₂₉H₄₄O₆
Molecular Weight:	488.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Polygala tenuifolia Willd
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0462 mL	10.2312 mL	20.4625 mL	40.9249 mL	51.1561 mL
5 mM	0.4092 mL	2.0462 mL	4.0925 mL	8.185 mL	10.2312 mL
10 mM	0.2046 mL	1.0231 mL	2.0462 mL	4.0925 mL	5.1156 mL
50 mM	0.0409 mL	0.2046 mL	0.4092 mL	0.8185 mL	1.0231 mL
100 mM	0.0205 mL	0.1023 mL	0.2046 mL	0.4092 mL	0.5116 mL

CFN99844	Phytolaccagenin	1802-12-6	532.7	C₃₁H₄₈O₇
CFN92195	Polygalic acid	1260-04-4	488.7	C₂₉H₄₄O₆
CFN93933	Medicagenic acid	599-07-5	502.68	C₃₀H₄₆O₆
CFN99109	Senegenin	2469-34-3	537.14	C₃₀H₄₅ClO₆
CFN96689	Quillaic acid	631-01-6	486.69	C₃₀H₄₆O₅
CFN92210	3-beta-O-(trans-p-Coumaroyl)maslinic acid	35482-91-8	618.9	C₃₉H₅₄O₆
CFN92208	3-beta-O-(cis-p-Coumaroyl)maslinic acid	69297-40-1	618.9	C₃₉H₅₄O₆
CFN92275	Eucalyptolic acid	189272-68-2	648.9	C₄₀H₅₆O₇
CFN96017	Camaldulenic acid	71850-15-2	470.7	C₃₀H₄₆O₄
CFN98397	Arjunic acid	31298-06-3	488.7	C₃₀H₄₈O₅