Polypodine B | CAS:18069-14-2 | Manufacturer ChemFaces

Polypodine B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Polypodine B shows growth-promoting effects on in vitro development of the larval endoparasitoid, Venturia canescens (Hymenoptera: Ichneumonidae).

In vitro:

J Insect Physiol. 2000 Apr;46(4):467-476.

Growth-promoting effects of ecdysteroids and juvenile hormone on in vitro development of the larval endoparasitoid, Venturia canescens (Hymenoptera: Ichneumonidae).[Pubmed: 12770211]

We previously reported that lipophorin, fetal bovine serum (FBS), and 20-hydroxyecdysone (20-HE) are essential for the development of the larval endoparasitoid Venturia canescens larvae in vitro. The present study was undertaken to determine the optimal concentrations of those three substances in the MGM-450 medium, and to examine the hormonal effects of ecdysteroids and juvenile hormone (JH) on the development of the parasitoid larvae in vitro.
METHODS AND RESULTS:
When the culture was started with embryos at the post-germband stage, concentrations of 3 mg/ml of lipophorin and 20% of FBS were most suitable for the development of the parasitoid. The growth-promoting effect of 20-HE increased in a concentration-dependent manner and peaked at a concentration of 1 &mgr;g/ml. Excess concentration led to malformations of the larvae. Three other ecdysteroids, ecdysone, 2-deoxy-20-hydroxyecdysone, and Polypodine B had the same effect, although their activity was lower than that of 20-HE. Cholesterol had no effect; most larvae failed to develop. When the medium was supplemented with JH, the duration of the developmental period was significantly shortened, but this hormone was not found to be essential.

In vivo:

J Insect Sci. 2010;10:13. doi: 10.1673/031.010.1301.

Dietary effects of four phytoecdysteroids on growth and development of the Indian meal moth, Plodia interpunctella.[Pubmed: 20575744 ]

METHODS AND RESULTS:
Using pure phytoecdysteroids isolated from Ajuga iva (L.) Schreber (Lamiales: Lamiaceae) and Silene nutans L. (Caryophyllales: Caryophyllaceae), plants known for their high ecdysteroid content, a study was carried out on the effects of ingestion of four different phytoecdysteroids (20-hydroxyecdysone, Polypodine B, ponasterone A and makisterone A) on the growth and development of the Indian meal moth, Plodia interpunctella Hübner (Lepidoptera: Pyralidae) larvae when added at a concentration of 200 ppm in their diet. The experiments clearly showed the susceptibility of P. interpunctella to phytoecdysteroid ingestion. The toxicity of phytoecdysteroids manifested itself by a decrease in larval weight, induction of cannibalism and an increase of mortality, together with disruption of development. The severity of the phytoecdysteroid effect on P. interpunctella depended on the structure of the molecule. The results demonstrate that the minimal structural differences existing between these four phytoecdysteroids significantly affected their toxicity toward P. interpunctella. Makisterone A was the most toxic of the four compounds towards P. interpunctella larvae.
CONCLUSIONS:
In conclusion, phytoecdysteroids ingestion evokes disruptive growth effects on P. interpunctella. This work supports a role for phytoecdysteroids in plant defence against phytophagous insects.

Polypodine B Description

Source:	The herbs of Achyranthes bidentata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Polypodine B
Price:
CAS No.:	18069-14-2
Catalog No.:	CFN89545
Molecular Formula:	C₂₇H₄₄O₈
Molecular Weight:	496.63 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Achyranthes bidentata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0136 mL	10.0679 mL	20.1357 mL	40.2714 mL	50.3393 mL
5 mM	0.4027 mL	2.0136 mL	4.0271 mL	8.0543 mL	10.0679 mL
10 mM	0.2014 mL	1.0068 mL	2.0136 mL	4.0271 mL	5.0339 mL
50 mM	0.0403 mL	0.2014 mL	0.4027 mL	0.8054 mL	1.0068 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.4027 mL	0.5034 mL

CFN90611	4-Beta-Hydroxycholesterol	17320-10-4	402.66	C₂₇H₄₆O₂
CFN90610	7Beta-Hydroxycholesterol	566-27-8	402.65	C₂₇H₄₆O₂
CFN91812	7-Ketocholesterol	566-28-9	400.6	C₂₇H₄₄O₂
CFN91647	7-Oxocholesteryl acetate	809-51-8	442.7	C₂₉H₄₆O₃
CFN90609	27-Hydroxycholesterol	20380-11-4	402.65	C₂₇H₄₆O₂
CFN91582	Cholest-4,6-diene-3-ol	14214-69-8	384.6	C₂₇H₄₄O
CFN99419	Ponasterone A	13408-56-5	464.6	C₂₇H₄₄O₆
CFN90616	Ajugasterone C	23044-80-6	480.64	C₂₇H₄₄O₇
CFN92515	Inokosterone	15130-85-5	480.6	C₂₇H₄₄O₇
CFN93571	25S-Inokosterone	19595-18-7	480.6	C₂₇H₄₄O₇