Propyl paraben | CAS:94-13-3 | Manufacturer ChemFaces

Propyl paraben

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Propyl paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics for over 50 years.

Targets:

Antifection

In vitro:

Journal of Antimicrobial Chemotherapy,2005,55(6):1013–1015.

Propyl paraben induces potassium efflux in Escherichia coli.[Reference: WebLink]

Parabens are currently used as antibacterial preservatives in pharmaceutical, cosmetic and food products but there are no precise data concerning their activity on bacterial membranes.
METHODS AND RESULTS:
We analysed the cytoplasmic potassium release during Propyl paraben addition by using a selective electrode. Various conditions were assayed to investigate the bacterial paraben susceptibility. We compared the activity of Propyl paraben with the activities of colicin A and polymyxin B. Propyl paraben induced potassium efflux that was related to the porin expression in the bacterial outer membrane. In addition, the presence of spermine, previously described as an efficient OmpF channel-blocker, protected susceptible cells against paraben activity.
CONCLUSIONS:
Propyl paraben induced potassium release in susceptible Escherichia coli cells similar to that observed with polymyxin B. Moreover, this efflux depended on porin channel activity. This permeabilizing effect is probably related to antibacterial properties of paraben molecules.

Propyl paraben Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Food & Chemical Toxicology, 2002, 40(12):0-1813.

Effects of propyl paraben on the male reproductive system.[Reference: WebLink]

Parabens are p-hydroxybenzoic acid ester compounds widely used as preservatives in foods, cosmetics, toiletries and pharmaceuticals. These compounds exert a weak estrogenic activity as determined by in vitro estrogen receptor assay and in vivo uterotrophic assay. In a previous study, it was demonstrated by the present author that exposure of post-weaning mammals to butyl paraben adversely affects the secretion of testosterone and the function of the male reproductive system.
METHODS AND RESULTS:
In the present study, it is shown that Propyl paraben also adversely affects the hormonal secretion and the male reproductive functions. Propyl paraben was administered to 3-week-old rats which were divided into four groups of eight animals each, at doses of 0.00, 0.01, 0.10 and 1.00% with the AIN93G modified diet. At the end of 4 weeks, the rats were sacrificed by decapitation and the weights of testes, epididymides, prostates, seminal vesicles and preputial glands were determined. There were no treatment-related effects of Propyl paraben on the organ weights in any of the study groups. The cauda epididymal sperm reserves and concentrations decreased in a dose-dependent manner and the difference was significant at dose of 0.10% and above. Daily sperm production and its efficiency in the testis of all groups receiving Propyl paraben significantly decreased.
CONCLUSIONS:
The serum testosterone concentration decreased in a dose-dependent manner and the decrease was significant in the group that received the highest dose. The exposure level at which this effect was observed is the same as the upper-limit acceptable daily intake (10 mg/kg body weight/day) of parabens in the European Community and Japan.

Product Name	Propyl paraben
Price:	$30 / 20mg
CAS No.:	94-13-3
Catalog No.:	CFN70226
Molecular Formula:	C₁₀H₁₂O₃
Molecular Weight:	180.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.5494 mL	27.7469 mL	55.4939 mL	110.9878 mL	138.7347 mL
5 mM	1.1099 mL	5.5494 mL	11.0988 mL	22.1976 mL	27.7469 mL
10 mM	0.5549 mL	2.7747 mL	5.5494 mL	11.0988 mL	13.8735 mL
50 mM	0.111 mL	0.5549 mL	1.1099 mL	2.2198 mL	2.7747 mL
100 mM	0.0555 mL	0.2775 mL	0.5549 mL	1.1099 mL	1.3873 mL

CFN90238	3,4,5-Tricaffeoylquinic acid	86632-03-3	678.59	C₃₄H₃₀O₁₅
CFN93220	Nuezhenidic acid	183238-67-7	452.36	C₁₇H₂₄O₁₄
CFN92693	Coelonin	82344-82-9	242.3	C₁₅H₁₄O₃
CFN92501	(-)-Lariciresinol	83327-19-9	360.4	C₂₀H₂₄O₆