Quercetin Dihydrate | CAS:6151-25-3 | Manufacturer ChemFaces

Quercetin Dihydrate

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $14.4 / In-stock
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Description:

Quercetin dihydrate loaded electrospun nanofibrous membrane show antimycotic effect on candida albicans. Clinoptilolite modified with quercetin dihydrate has shown better cytotoxicity compared with clinoptilolite modified with quercetin. The supplementation of quercetin dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.

Targets:

HMG-CoA Reductase | SOD | Antifection

In vitro:

Microporous and Mesoporous Materials, 2012,147( 1): 59-67.

Modified natural clinoptilolite with quercetin and quercetin dihydrate and the study of their anticancer activity[Reference: WebLink]

Natural zeolite of the clinoptilolite type and their modified forms CTQ and CTQD with low content (0.06% and 1%) of Q and QD have been used for the study of their anticancer activity.
METHODS AND RESULTS:
Carcinoma cell lines Jurkat, CEM, HeLa, MCF7, A549 and MDA were treated with various amounts of natural clinoptilolite and their modified forms CTQ and CTQD. The water content of the channel system influences the cytotoxicity of zeolite. The results of the study of pure CT thermally activated at two different temperatures 110 and 400 °C confirmed the better cytotoxicity of CT activated at 110 °C (CT110) with higher content of water in comparison with CT activated at 400 °C (CT400).
CONCLUSIONS:
Clinoptilolite modified with Quercetin Dihydrate (CTQD) has shown better cytotoxicity compared with clinoptilolite modified with quercetin (CTQ).

In vivo:

Int J Vitam Nutr Res. 2002 May;72(3):161-9.

Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.[Pubmed: 12098884 ]

This study was designed to test the lipid-lowering and antioxidant activity of two bioflavonoids, Quercetin Dihydrate and gallate.
METHODS AND RESULTS:
Four groups of rats were given a semisynthetic diet containing 10 g cholesterol/kg for six weeks. The control group received only a high-cholesterol diet, whereas the other three groups received a diet including 1 g lovastatin, 1 g Quercetin Dihydrate, or 1 g gallate/kg. The Quercetin Dihydrate and gallate supplements both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those of the control. The hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was significantly lowered by the Quercetin Dihydrate when compared to the other groups, while the hepatic acyl CoA: cholesterol acyltransferase (ACAT) activity was only significantly higher in the control group. The overall potential for antioxidant protection was significantly enhanced by the Quercetin Dihydrate and gallate supplements through lowering the plasma and hepatic thiobarbituric acid reactive substances (TBARS) levels and increasing the hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in high-cholesterol-fed rats.
CONCLUSIONS:
These results suggest that the supplementation of Quercetin Dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.

Quercetin Dihydrate Description

Source:	The flower buds of Sophora flavescens Ait.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Biotechnol Biomater 2012, 2(6):248.

Antimycolytic effect of quercetin dihydrate loaded electrospun nanofibrous membrane on Candida albicans[Reference: WebLink]

Candida is an opportunistic fungus, known to cause systemic and life threatening infections in immunosuppressed patients. In our attempt to dealt with this ominous fungal pathogen we have successfully fabricated ultrafine poly (D,L-lactide-coglycolide), PLGA, nanofibrous membrane loaded with different concentrations of Quercetin Dihydrate, natural flavones with antioxidant and antimycolytic activity, using acetone-dichloromethane as solvent system.
CONCLUSIONS:
The bulk fabrication of these nanofibrous membrane was performed via electrospinning technique. The morphology of resulting nanofibrous membrane with or without Quercetin Dihydrate was examined using field emission scanning electron microscopy (FE-SEM). The nanofibrous membrane was also subjected to detailed analysis by Fourier transform infrared spectrometry (FTIR). The antimycolytic effect of these Quercetin Dihydrate loaded nanofibrous membrane on to the viability of C. albicans cells was established using modified XTT (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) reduction assay in 6 well polystyrene microtiter plates.

Product Name	Quercetin Dihydrate
Price:	$40 / 20mg
CAS No.:	6151-25-3
Catalog No.:	CFN90931
Molecular Formula:	C₁₅H₁₄O₉
Molecular Weight:	338.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The flower buds of Sophora flavescens Ait.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Antifungal Compound Library Anti-hyperlipidemic Compound Library Flavonoids Compound Library SOD Inhibitor Library HMG-CoA Reductase Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.956 mL	14.7798 mL	29.5596 mL	59.1191 mL	73.8989 mL
5 mM	0.5912 mL	2.956 mL	5.9119 mL	11.8238 mL	14.7798 mL
10 mM	0.2956 mL	1.478 mL	2.956 mL	5.9119 mL	7.3899 mL
50 mM	0.0591 mL	0.2956 mL	0.5912 mL	1.1824 mL	1.478 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.5912 mL	0.739 mL

CFN80019	1-Octacosanoyl glyceride	71035-02-4	498.83	C₃₁H₆₂O₄
CFN97721	Serpentinic acid	605-14-1	335.38	C₂₀H₁₉N₂O₃
CFN98039	Cannabichromene	20675-51-8	314.5	C₂₁H₃₀O₂
CFN97561	Ailanthone	981-15-7	376.4	C₂₀H₂₄O₇