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Rauvovertine B
Rauvovertine B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Rauvovertine B
Price:
CAS No.: 2055073-72-6
Catalog No.: CFN89449
Molecular Formula: C19H22N2O3
Molecular Weight: 326.38 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The stems of Rauvolfia verticillata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Rauvovertine B shows cytotoxicity in vitro against human tumor cell lines.
Rauvovertine B Description
Source: The stems of Rauvolfia verticillata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0639 mL 15.3196 mL 30.6391 mL 61.2783 mL 76.5978 mL
5 mM 0.6128 mL 3.0639 mL 6.1278 mL 12.2557 mL 15.3196 mL
10 mM 0.3064 mL 1.532 mL 3.0639 mL 6.1278 mL 7.6598 mL
50 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.2256 mL 1.532 mL
100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Fitoterapia. 2015 Dec;107:44-48.
Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.[Pubmed: 26474672 ]

METHODS AND RESULTS:
Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), Rauvovertine B (3), 17-epi-Rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution.
CONCLUSIONS:
The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
CFN89451Rauvovertine A2055073-75-9326.38C19H22N2O3
CFN976073-Hydroxysarpagine857297-90-6326.39C19H22N2O3
CFN9868410-Hydroxydihydroperaksine451478-47-0328.4 C19H24N2O3
CFN98712N-Methylsarpagine methosalt47418-70-2339.5 C21H27N2O2
CFN98759Sarpagine482-68-8310.4 C19H22N2O2
CFN98852Lochnerine522-47-4324.4 C20H24N2O2
CFN99240(Z)-Akuammidine113973-31-2352.4 C21H24N2O3
CFN99677Dihydroperaksine16100-84-8312.4 C19H24N2O2
CFN99655Peraksine15527-80-7310.4 C19H22N2O2
CFN89449Rauvovertine B2055073-72-6326.38C19H22N2O3
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