Kaempferol 3-gentiobioside | CAS:22149-35-5

Kaempferol 3-gentiobioside

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Description:

Kaempferol 3-O-gentiobioside has antiinflammatory activity, shows weak inhibitory effects on Concanavalin A-induced histamine release, 5-lipoxygenase, and COX-1.

Targets:

Histamine Receptor | COX

In vitro:

J Enzyme Inhib Med Chem. 2009 Feb;24(1):230-3.

Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro.[Pubmed: 18825536]

A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia.
METHODS AND RESULTS:
Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-beta-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), Kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 microM.

Kaempferol 3-gentiobioside Description

Source:	The barks of Cinnamomum cassia.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Yakugaku Zasshi. 2001 Nov;121(11):817-20.

A stabilized flavonoid glycoside in heat-treated Cassia alata leaves and its structural elucidation.[Pubmed: 11725550]

Heat-treated leaves of Cassia alata were studied for any change in chemical constituents using sun dried leaves as the reference standard.
METHODS AND RESULTS:
A high concentration of a constituent was observed in the heat-treated leaves. Spectroscopic studies revealed the structure of the constituent as Kaempferol 3-gentiobioside, which has not yet been detected in the Cassia species. In a stability study disappearance of Kaempferol 3-gentiobioside was noted in the sun dried leaves while there was little or no change in the Kaempferol 3-gentiobioside concentration in the heat-treated leaves when incubated in an aqueous solution, suggesting a possible presence of enzymatic activities in the sun dried leaves.
CONCLUSIONS:
Therefore, heat-treatment may be a good method to stabilize Kaempferol 3-gentiobioside in Cassia alata leaves.

Product Name	Kaempferol 3-gentiobioside
Price:	$80 / 20mg
CAS No.:	22149-35-5
Catalog No.:	CFN92384
Molecular Formula:	C₂₇H₃₀O₁₆
Molecular Weight:	610.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The barks of Cinnamomum cassia.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Flavonoids Compound Library Histamine Receptor Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.638 mL	8.19 mL	16.38 mL	32.76 mL	40.95 mL
5 mM	0.3276 mL	1.638 mL	3.276 mL	6.552 mL	8.19 mL
10 mM	0.1638 mL	0.819 mL	1.638 mL	3.276 mL	4.095 mL
50 mM	0.0328 mL	0.1638 mL	0.3276 mL	0.6552 mL	0.819 mL
100 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.3276 mL	0.4095 mL

CFN92372	Kaempferol 3-O-beta-sophoroside	19895-95-5	610.5	C₂₇H₃₀O₁₆
CFN97804	Biorobin	17297-56-2	594.53	C₂₇H₃₀O₁₅
CFN70287	Datiscin	16310-92-2	594.5	C₂₇H₃₀O₁₅
CFN99830	Nicotiflorin	17650-84-9	594.5	C₂₇H₃₀O₁₅
CFN90233	6-Methoxykaempferol 3-O-rutinoside	403861-33-6	624.6	C₂₈H₃₂O₁₆
CFN92384	Kaempferol 3-gentiobioside	22149-35-5	610.5	C₂₇H₃₀O₁₆
CFN95366	Ternatumoside II	1473419-87-2	594.5	C₂₇H₃₀O₁₅
CFN90342	Helicianeoide A	496066-82-1	726.63	C₃₂H₃₈O₁₉
CFN91162	Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside	476617-49-9	756.7	C₃₃H₄₀O₂₀
CFN93560	Camelliaside B	131573-90-5	726.6	C₃₂H₃₈O₁₉