Schisanlactone A | CAS:87164-31-6 | Manufacturer ChemFaces

Schisanlactone A

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Schisanlactone A is a dimerization inhibitor, with an IC50 value of 5.0 microg/mL; it also shows appreciable inhibitory activity against HIV-1 protease with the IC50 value of 20 microM. Schisanlactone A shows cytotoxicity against KB (a human epidermal carcinoma) cells with the IC50 value of 63.3 uM.

Targets:

HIV

In vitro:

J Nat Prod. 2009 Nov;72(11):2019-23.

Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.[Pubmed: 19813754 ]

METHODS AND RESULTS:
A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0 microg/mL, respectively.
CONCLUSIONS:
Kinetic studies using Zhang-Poorman and Lineweaver plots revealed that compound 2 competitively inhibited the active site of the enzyme, whereas the tetracyclic triterpene Schisanlactone A, previously isolated from the same fungus, was a dimerization inhibitor, with an IC50 value of 5.0 microg/mL. The previous findings were also confirmed by the virtual docking of both compounds with HIV-1 protease crystal structure.

Fitoterapia. 2013 Dec;91:125-7.

Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis.[Pubmed: 24001711 ]

METHODS AND RESULTS:
Three novel steroids (1-3), named cattienoids A-C together with Schisanlactone A (4), were isolated from fruiting bodies of Tomophagus cattienensis (Ganodermataceae)-a new mushroom recently collected from Cattien National Park, in Viet Nam. They possess an unusual seven membered lactone ring, derived from lanostane-type triterpenoids. Their structures were determined by spectroscopic methods. In addition, compounds 2 and 4 showed cytotoxicity against KB (a human epidermal carcinoma) cells with their IC50 values of 91.2 and 63.3 μM, respectively.
CONCLUSIONS:
These compounds have neither antimicrobial activity nor inhibition of the tyrosinase.

Schisanlactone A Description

Source:	The herbs of Kadsura longipedunculata Finet.et Gagnep
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Schisanlactone A
Price:
CAS No.:	87164-31-6
Catalog No.:	CFN92212
Molecular Formula:	C₃₀H₄₀O₄
Molecular Weight:	464.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Kadsura longipedunculata Finet.et Gagnep
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Cytotoxic Compound Library Triterpenoids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1519 mL	10.7596 mL	21.5193 mL	43.0385 mL	53.7981 mL
5 mM	0.4304 mL	2.1519 mL	4.3039 mL	8.6077 mL	10.7596 mL
10 mM	0.2152 mL	1.076 mL	2.1519 mL	4.3039 mL	5.3798 mL
50 mM	0.043 mL	0.2152 mL	0.4304 mL	0.8608 mL	1.076 mL
100 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.4304 mL	0.538 mL

CFN98600	Semialactone	366450-46-6	468.7	C₃₀H₄₄O₄
CFN92277	Schisanlactone D	92051-26-8	452.7	C₃₀H₄₄O₃
CFN92212	Schisanlactone A	87164-31-6	464.7	C₃₀H₄₀O₄
CFN92349	Schisanlactone C	92051-27-9	480.7	C₃₀H₄₀O₅
CFN96352	Longipedlactone J	1011762-93-8	536.7	C₃₂H₄₀O₇