Science | Nature | Cell | View More
Natural Products
Scutebata B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Scutebata B
Price:
CAS No.: 1207181-58-5
Catalog No.: CFN99323
Molecular Formula: C35H39NO10
Molecular Weight: 633.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Scutellaria barbata D.Don
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Tokyo Woman's Christian University (Japan)
  • University of Mysore (India)
  • Worcester Polytechnic Institute (USA)
  • University Medical Center Mainz (Germany)
  • Funda??o Universitária de Dese... (Brazil)
  • Osmania University (India)
  • Charles Sturt University (Denmark)
  • The Institute of Cancer Research (United Kingdom)
  • Chang Gung University (Taiwan)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Imperial College London (United Kingdom)
  • More...
Package
Featured Products
Myricetin 3-O-galactoside

Catalog No: CFN97817
CAS No: 15648-86-9
Price: $318/10mg
Cannabidiolic acid

Catalog No: CFN99356
CAS No: 1244-58-2
Price: $413/5mg
Deoxypodophyllotoxin

Catalog No: CFN99888
CAS No: 19186-35-7
Price: $268/10mg
Loganin

Catalog No: CFN99858
CAS No: 18524-94-2
Price: $30/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Platycodin D

Catalog No: CFN98134
CAS No: 58479-68-8
Price: $70/20mg
Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
Glaucine

Catalog No: CFN90408
CAS No: 475-81-0
Price: $188/20mg
Ginsenoside Rf

Catalog No: CFN99976
CAS No: 52286-58-5
Price: $188/20mg
Delta 7-avenasterol

Catalog No: CFN92240
CAS No: 23290-26-8
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Scutebata B inhibited NO production efficiently with IC50 values of lower than 50 μM.
Targets: NO
In vitro:
Chemistry & Biodiversity, 2017, 14(11).
Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Reference: WebLink]

METHODS AND RESULTS:
The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), Scutebata B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively.
CONCLUSIONS:
This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.
Scutebata B Description
Source: The herbs of Scutellaria barbata D.Don
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Safflospermidine A

Catalog No: CFN95255
CAS No: N/A
Price: $413/5mg
4,4-di(4-hydroxy-3-methoxyphenly)-...

Catalog No: CFN95200
CAS No: 913643-31-9
Price: $368/5mg
Sphenanlignan

Catalog No: CFN95245
CAS No: 866347-36-6
Price: $318/5mg
1,3,6-Tri-O-galloylglucose

Catalog No: CFN95043
CAS No: 18483-17-5
Price: $318/10mg
7-(4-Hydroxyphenyl)-1-phenyl-4-hep...

Catalog No: CFN95140
CAS No: 100667-52-5
Price: $318/5mg
Batatasin IV

Catalog No: CFN95319
CAS No: 60347-67-3
Price: $318/5mg
Orthosiphol A

Catalog No: CFN95442
CAS No: 142741-25-1
Price: $318/5mg
24-Hydroxymomordicine III

Catalog No: CFN95169
CAS No: N/A
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.578 mL 7.8902 mL 15.7803 mL 31.5607 mL 39.4508 mL
5 mM 0.3156 mL 1.578 mL 3.1561 mL 6.3121 mL 7.8902 mL
10 mM 0.1578 mL 0.789 mL 1.578 mL 3.1561 mL 3.9451 mL
50 mM 0.0316 mL 0.1578 mL 0.3156 mL 0.6312 mL 0.789 mL
100 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3156 mL 0.3945 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Natural Products, 2010, 73(2):233-236.
Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Reference: WebLink]

METHODS AND RESULTS:
Seven new neoclerodane diterpenoids, scutebata A, Scutebata B, scutebata C, scutebata D, scutebata E, scutebata F, scutebata G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1.
CONCLUSIONS:
Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.
Myricetin 3-O-galactoside

Catalog No: CFN97817
CAS No: 15648-86-9
Price: $318/10mg
Cannabidiolic acid

Catalog No: CFN99356
CAS No: 1244-58-2
Price: $413/5mg
Deoxypodophyllotoxin

Catalog No: CFN99888
CAS No: 19186-35-7
Price: $268/10mg
Loganin

Catalog No: CFN99858
CAS No: 18524-94-2
Price: $30/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Platycodin D

Catalog No: CFN98134
CAS No: 58479-68-8
Price: $70/20mg
Delphinidin-3-O-glucoside chloride

Catalog No: CFN92038
CAS No: 6906-38-3
Price: $238/10mg
Glaucine

Catalog No: CFN90408
CAS No: 475-81-0
Price: $188/20mg
Ginsenoside Rf

Catalog No: CFN99976
CAS No: 52286-58-5
Price: $188/20mg
Delta 7-avenasterol

Catalog No: CFN92240
CAS No: 23290-26-8
Price: $ / mg
Tags: buy Scutebata B | Scutebata B supplier | purchase Scutebata B | Scutebata B cost | Scutebata B manufacturer | order Scutebata B | Scutebata B distributor