Semialactone | CAS:366450-46-6 | Manufacturer ChemFaces

Semialactone

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Semialactone shows inhibitory activities on human acyl-CoA:cholesterol acyltransferase(hACAT)1 with IC50 values of 79.1 uM and on human hACAT2 with IC50 values of 76.9 uM, it may be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.

Targets:

hACAT1 | hACAT2

In vitro:

Appl. Biol.Chem.,2010, 53(4):417-21.

Human Acyl-CoA:Cholesterol Acyltransferase-inhibiting Dammarane Triterpenes from Rhus chinensis[Reference: WebLink]

METHODS AND RESULTS:
In the process of screening for anti-human acyl-CoA:cholesterol acyltransferase (hACAT) agents from plant resources, we found that the 80% methanolic extract of Rhus chinensis (R. chinensis) exhibited significant antioxidative and hACAT activities in rats. Two compounds were isolated as active principles from the ethyl acetate soluble fraction of the branches of R. chinensis. The structures of compounds 1 and 2 were determined as hydroxydammarenone and Semialactone, respectively, by means of MS and NMR spectroscopic analysis. Compound 1 has been isolated from this plant for the first time. Compounds 1 and 2 showed inhibitory activities on both human ACAT1 with IC50 values of 12.4, and 79.1 μM and on human ACAT2 with IC50 values of 30.5 and 76.9 μM, respectively.
CONCLUSIONS:
These results suggested that R. chinensis containing dammarane triterpenes 1 and 2 might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.

Semialactone Description

Source:	The barks of Rhus javanica L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Semialactone
Price:
CAS No.:	366450-46-6
Catalog No.:	CFN98600
Molecular Formula:	C₃₀H₄₄O₄
Molecular Weight:	468.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The barks of Rhus javanica L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-hyperlipidemic Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1336 mL	10.6678 mL	21.3356 mL	42.6712 mL	53.339 mL
5 mM	0.4267 mL	2.1336 mL	4.2671 mL	8.5342 mL	10.6678 mL
10 mM	0.2134 mL	1.0668 mL	2.1336 mL	4.2671 mL	5.3339 mL
50 mM	0.0427 mL	0.2134 mL	0.4267 mL	0.8534 mL	1.0668 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.4267 mL	0.5334 mL

CFN98600	Semialactone	366450-46-6	468.7	C₃₀H₄₄O₄
CFN92277	Schisanlactone D	92051-26-8	452.7	C₃₀H₄₄O₃
CFN92212	Schisanlactone A	87164-31-6	464.7	C₃₀H₄₀O₄
CFN92349	Schisanlactone C	92051-27-9	480.7	C₃₀H₄₀O₅
CFN96352	Longipedlactone J	1011762-93-8	536.7	C₃₂H₄₀O₇