Soyasaponin II | CAS:55319-36-3 | Manufacturer ChemFaces

Soyasaponin II

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $556.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1. Soyasaponin II has hepatoprotective actions towards immunologically induced liver injury on primary cultured rat hepatocytes. It can inhibit the conversion of fibrinogen to fibrin, it also can promote activation of the fibrinolytic system in a plasminogen-containing fibrin plate. Soyasaponins are a potential antitumor compound and the apoptosis induced by soyasaponins is a key antitumor mechanism.

Targets:

Influenza virus | HIV | HSV

In vitro:

Planta Med., 1997, 63(2):102-5.

Inhibitory activity of soyasaponin II on virus replication in vitro.[Pubmed: 9140220]

METHODS AND RESULTS:
The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
CONCLUSIONS:
The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. When acyclovir and Soyasaponin II were evaluated in combination for anti-HSV-1 activity, additive antiviral effects were observed for this virus.

In vivo:

Theranostics . 2020 Feb 3;10(6):2714-2726.

Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice[Pubmed: 32194830]

Abstract Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of Soyasaponin II in acute liver failure and establish the underlying mechanism. Methods: Lipopolysaccharide/D-galactosamine (LPS/GalN) was employed to induce acute liver failure. We applied liquid chromatography and mass spectrometry (LC/MS) to characterize the changes of Soyasaponin II levels in the cecal content and liver. Transcriptomics and proteomics analysis were used to evaluate the functional molecule mediated by Soyasaponin II in macrophages. Results: LPS/GalN administration markedly decreased fecal and hepatic Soyasaponin II levels. Soyasaponin II treatment protected mice against LPS/GalN induced acute liver injury. Additionally, Soyasaponin II markedly diminished Y-Box Binding Protein 1 (YB-1) phosphorylation and nuclear translocation, Nlrp3 inflammasome priming, and interleukin 1β (Il-1β) production in macrophages. Phosphorylated YB-1 could activate Nlrp3 mRNA transcription by binding the promoter region. Finally, immunofluorescence analysis showed elevated p-YB-1 nuclear translocation in macrophages of acute liver failure patients compared to controls. Conclusion: Our data shows that Soyasaponin II which serves as a novel inhibitor for YB-1 phosphorylation and Nlrp3 inflammasome priming could protect mice against LPS/GalN induced acute liver failure. Keywords: Nlrp3-inflammasome; YB-1; acute liver failure; Soyasaponin II.

Soyasaponin II Description

Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Planta Med., 1998, 64(3):233-6.

Structure-hepatoprotective relationships study of soyasaponins I-IV having soyasapogenol B as aglycone.[Pubmed: 9581521 ]

As a part of our study on the leguminous plants, we investigated the constituents of the aerial parts of Glycine soya.
METHODS AND RESULTS:
We isolated and identified four known saponins, soyasaponins I, II, III, and IV which have the same aglycone, soyasapogenol B. As a part of our studies concerning hepatoprotective drugs, we also examined the hepatoprotective actions of these saponins towards immunologically induced liver injury on primary cultured rat hepatocytes. The action of Soyasaponin II was almost comparable with that of soyasaponin I, whereas those of Soyasaponin III and IV were more effective than soyasaponins I and II. This means that the disaccharide group shows greater action than the trisaccharide group. Furthermore, the saponin having a hexosyl unit shows a slightly greater action than that of the pentosyl unit in each disaccharide group or trisaccharide group.
CONCLUSIONS:
Structure-activity relationships suggest that the sugar moiety linked at C-3 may play an important role in hepatoprotective actions of soybean saponins.

Product Name	Soyasaponin II
Price:	$318 / 5mg
CAS No.:	55319-36-3
Catalog No.:	CFN93159
Molecular Formula:	C₄₇H₇₆O₁₇
Molecular Weight:	913.1 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Hepatoprotective Compound Library Antiviral Compound Library Anticoagulants Compound Library Triterpenoids Compound Library Influenza virus Inhibitor Library HSV Inhibitor Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0952 mL	5.4759 mL	10.9517 mL	21.9034 mL	27.3793 mL
5 mM	0.219 mL	1.0952 mL	2.1903 mL	4.3807 mL	5.4759 mL
10 mM	0.1095 mL	0.5476 mL	1.0952 mL	2.1903 mL	2.7379 mL
50 mM	0.0219 mL	0.1095 mL	0.219 mL	0.4381 mL	0.5476 mL
100 mM	0.011 mL	0.0548 mL	0.1095 mL	0.219 mL	0.2738 mL

CFN93251	Soyasaponin IV	108906-97-4	767.0	C₄₁H₆₆O₁₃
CFN91596	Soyasaponin III	55304-02-4	796.99	C₄₂H₆₈O₁₄
CFN93159	Soyasaponin II	55319-36-3	913.1	C₄₇H₇₆O₁₇
CFN90456	Soyasaponin Bb	51330-27-9	943.12	C₄₈H₇₈O₁₈
CFN90722	Soyasaponin Ba	114590-20-4	959.1	C₄₈H₇₈O₁₉
CFN90455	Soyasaponin Aa	117230-33-8	1365.46	C₆₄H₁₀₀O₃₁
CFN90773	Soyasaponin Ab	118194-13-1	1437.6	C₆₇H₁₀₄O₃₃
CFN90774	Soyasaponin Ac	133882-74-3	1421.6	C₆₇H₁₀₄O₃₂
CFN80325	Pedunsaponin C	272120-53-3	795.0	C₄₂H₆₆O₁₄
CFN80329	Pedunsaponin A	250613-27-5	811.0	C₄₂H₆₆O₁₅