Ssioriside | CAS:126882-53-9 | Manufacturer ChemFaces

Ssioriside

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Ssioriside shows moderate antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.

In vitro:

Nat.Prod.Sci., 2005, 11(2):97-102.

The chemical constituents and their antioxidant activity of the stem of Rhododendron mucronulatum[Reference: WebLink]

METHODS AND RESULTS:
From the n-BuOH soluble fraction of the 70% aqueous acetone extract of Rhododendron mucronulatum stem, twelve compounds were isolated. On the basis of spectral data, they were identified as scopoletin (1), (+)-taxifolin (2), quercetin (3), (-)-catechin (4), (+)-epicatechin (5), scopolin (6), lyoniside (7), Ssioriside (8), fraxin (9), (+)-lyoniresinol-3α-O-β-D- glucopyranoside (10), (+)-taxifolin-3-O-α-L-arabinopyranoside (11), and astragalin (12), respectively. All isolated compounds were tested antioxidant activity against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical.
CONCLUSIONS:
Compounds 2 and 3 showed the potent antioxidant activity, and compounds 5, 8, and 11 showed moderate activity.

Ssioriside Description

Source:	The herbs of Prunus ssiori
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Planta Med. 2011 Mar;77(5):441-9.

Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells.[Pubmed: 21049397]

Since cellular senescence involves organismal aging as well as diverse diseases, aging intervention might contribute to inhibit the aging process as well as aging-associated diseases.
METHODS AND RESULTS:
We tried to search for effective compounds from the root bark of ULMUS DAVIDIANA that are able to inhibit cellular senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Twenty-two compounds from the root bark of U. DAVIDIANA were isolated and screened for their inhibitory effects on adriamycin-induced cellular senescence by measuring senescence-associated β-galatosidase (SA- β-gal) activity. Among twenty-two compounds isolated, epifriedelanol (3), Ssioriside (15), and catechin-7-O- β-D-glucopyranoside (22) had inhibitory effects on adriamycin-induced cellular senescence in HDFs. Friedelin (2), epifriedelanol (3), and catechin-7-O- β-apiofuranoside (18) were active in HUVECs. In particular, epifriedelanol (3) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs.
CONCLUSIONS:
These results suggest that epifriedelanol (3) reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(11):1740-6.

[Lignans from Machilus robusta].[Pubmed: 24010288]

Eighteen lignans were isolated from an ethanol extract of Machilus robusta by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20 and reversed-phase HPLC.
METHODS AND RESULTS:
Their structures were identified by spectroscopic data analysis as isolariciresinol-9'-O-beta-D-xylopyranoside (1), (+)-5'-methoxy-isolariciresinol-9'-O-beta-D-xylopyranoside(2), lyoniresinol-9'-O-beta-D-xylopyranoside(3), (+)-(8S, 8'S) -4, 4'-dihydroxy-3, 3', 5, 5'-tetramethoxylignan-9, 9'-diol 9-O-beta-D-xylopyranoside (Ssioriside, 4), lyoniresinol (5), meso-dihydroguaiaretic acid (6), (+)-(8S, 8'R)-3', 4, 4'-trihydroxy-3'-methoxylignan (7), (8S, 8'R)-4'-hydroxy-3, 3', 4-trimethoxylignan (meso-monomethyl dihydroguaiaretic acid, 8), (+)-guaiacin (9), isoguaiacin (10), (-)-(7'R, 8R, 8'R)-4, 4'-dihydroxy-3, 3', 5-trimethoxy-2, 7'-cyclolignan (11), henricine B (12), (-)-(7S, 7'S, 8R, 8'R)-4, 4'-dihydroxy-3, 3', 5, 5'-tetramethoxy-7, 7'-epoxylignan-9, 9'-dio] (7S, 7'S, 8R, 8'R-icariol A2, 13), (+)-(7R, 8R, 7'E)-4-hydroxy-3, 5'-dimethoxy-7, 4'-epoxy-8, 3'-neolignan-7'-ene (licarin A, 14), nectandrin B (15), machilin-I (16), (-)-pinoresinol (17), and (-)-syringaresinol (18).
CONCLUSIONS:
All compounds were isolated from this plant for the first time. In the preliminary assay, compound 17 showed inhibitory activity against NO secretion of mouse peritoneal macrophages with an inhibition rate of 72.2% at 10 micromol x L(-1).

Product Name	Ssioriside
Price:
CAS No.:	126882-53-9
Catalog No.:	CFN99379
Molecular Formula:	C₂₇H₃₈O₁₂
Molecular Weight:	554.6 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Prunus ssiori
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8031 mL	9.0155 mL	18.031 mL	36.062 mL	45.0775 mL
5 mM	0.3606 mL	1.8031 mL	3.6062 mL	7.2124 mL	9.0155 mL
10 mM	0.1803 mL	0.9016 mL	1.8031 mL	3.6062 mL	4.5078 mL
50 mM	0.0361 mL	0.1803 mL	0.3606 mL	0.7212 mL	0.9016 mL
100 mM	0.018 mL	0.0902 mL	0.1803 mL	0.3606 mL	0.4508 mL

CFN97133	Dihydroguaiaretic acid	66322-34-7	330.4	C₂₀H₂₆O₄
CFN98539	Anwulignan	107534-93-0	328.41	C₂₀H₂₄O₄
CFN95501	erythro-Austrobailignan-6	114127-24-1	328.4	C₂₀H₂₄O₄
CFN92717	Schineolignin B	1352185-26-2	374.5	C₂₂H₃₀O₅
CFN95245	Sphenanlignan	866347-36-6	358.4	C₂₁H₂₆O₅
CFN95221	Arisanschinin E	1333378-33-8	360.5	C₂₁H₂₈O₅
CFN96694	Pregomisin	66280-26-0	390.47	C₂₂H₃₀O₆
CFN89236	Anhydrosecoisolariciresinol	29388-33-8	344.40	C₂₀H₂₄O₅
CFN96711	4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	1206464-65-4	374.43	C₂₁H₂₆O₆
CFN98363	Secoisolariciresinol	29388-59-8	362.4	C₂₀H₂₆O₆