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Tenacigenoside A
Tenacigenoside A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tenacigenoside A
Price:
CAS No.: 920502-42-7
Catalog No.: CFN97482
Molecular Formula: C35H56O12
Molecular Weight: 668.8 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Marsdenia tenacissima
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tenacigenoside A and 11α-O-benzoyl-12β-O-acetyltenacigenin B (TGTB) can significantly increase tumor cell apoptosis on lymphoma bearing mice primarily through down-regulation of BCL2 and BCL-XL, and up-regulation of BID.
Targets: Bcl-2/Bax
In vitro:
Leuk Lymphoma. 2015 May 5:1-30.
Marsdenia tenacssima and its functional components inhibits proliferation, induces apoptosis of human Burkitt's leukemia/lymphoma cell in vitro and in vivo.[Pubmed: 25942381]
Burkitt lymphoma is a fast growing non-Hodgkin lymphoma that occurs primarily in young males. The causes of Burkitt lymphoma include chromosome rearrangement and virus infection, but accurate and complete reasons remain to be discovered. The available treatment for Burkitt lymphoma is chemotherapy and radiation therapy. It is a highly aggressive B-cell neoplasm with not all patients cured, in spite of current therapies.
METHODS AND RESULTS:
This study evaluated the effects of traditional Chinese medicine Marsdenia tenacssima (MTE) and its component compound Tenacigenoside A (TGTA) and 11α-O-benzoyl-12β-O-acetyltenacigenin B (TGTB) on human Burkitt lymphoma growth. It was observed that MTE, TGTA or TGTB inhibited cell growth and induced apoptosis of Burkitt lymphoma cells in culture. In lymphoma bearing NOD/SCID nude mice, both TGTA and TGTB inhibited tumor growth and improved animal survival.
CONCLUSIONS:
TGTA and TGTB significantly increased tumor cell apoptosis on lymphoma bearing mice, primarily through down-regulation of BCL2 and BCL-XL and up-regulation of BID.
Tenacigenoside A Description
Source: The herbs of Marsdenia tenacissima
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4952 mL 7.4761 mL 14.9522 mL 29.9043 mL 37.3804 mL
5 mM 0.299 mL 1.4952 mL 2.9904 mL 5.9809 mL 7.4761 mL
10 mM 0.1495 mL 0.7476 mL 1.4952 mL 2.9904 mL 3.738 mL
50 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5981 mL 0.7476 mL
100 mM 0.015 mL 0.0748 mL 0.1495 mL 0.299 mL 0.3738 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN908773-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B1260252-18-3781.0C41H64O14
CFN90428Tenacissoside H191729-45-0794.97C42H66O14
CFN97795Tenacissoside G191729-43-8792.96C42H64O14
CFN97794Tenacissoside I191729-44-9814.97C44H62O14
CFN97890Dregeoside Da198665-65-7815.0C42H70O15
CFN97588Dregeoside Ga198665-66-8941.17C49H80O17
CFN97790Dregeoside Aa120230-41-5939.15C49H78O17
CFN89258Otophylloside F250217-73-3909.11C48H76O16
CFN96964Otophylloside B106758-54-7923.13C49H78O16
CFN80437Qingyangshengenin A106644-33-1933.09C49H72O17
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