Thevetin B | CAS:27127-79-3 | Manufacturer ChemFaces

Thevetin B

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Size /Price /Stock	10 mM * 1 mL in DMSO / $820.8 / In-stock
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Description:

Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.

Targets:

Sodium Channel | ATPase | Potassium Channel

In vitro:

Forensic Sci Int. 2012 Feb 10;215(1-3):146-51.

Method validation of a survey of thevetia cardiac glycosides in serum samples.[Pubmed: 21376490]

A sensitive and specific liquid chromatography tandem mass spectrometry (HPLC-ESI(+)-MS/MS) procedure was developed and validated for the identification and quantification of Thevetin B and further cardiac glycosides in human serum. The seeds of Yellow Oleander (Thevetia peruviana) contain cardiac glycosides that can cause serious intoxication.
METHODS AND RESULTS:
A mixture of six thevetia glycosides was extracted from these seeds and characterized. Thevetin B, isolated and efficiently purified from that mixture, is the main component and can be used as evidence. Solid phase extraction (SPE) proved to be an effective sample preparation method. Digoxin-d3 was used as the internal standard. Although ion suppression occurs, the limit of detection (LOD) is 0.27 ng/ml serum for Thevetin B. Recovery is higher than 94%, and accuracy and precision were proficient.
CONCLUSIONS:
Method refinement was carried out with regard to developing a general screening method for cardiac glycosides. The assay is linear over the range of 0.5-8 ng/ml serum. Finally, the method was applied to a case of thevetia seed ingestion.

Thevetin B Description

Source:	The herbs of Thevetia peruviana
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Can J Physiol Pharmacol. 1977 Apr;55(2):170-9.

Antagonism of biogenic amine-induced depression of cerebral cortical neurones by Na+, K+-ATPase in inhibitors.[Pubmed: 141320]

METHODS AND RESULTS:
The effects of iontophoretically applied Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors (ouabain, digitoxin, digitoxigenin, strophanthin K, strophanthidin, thevetin A and Thevetin B, ethacrynate, and harmaline) on the depression of rat cerebral cortical neurones by noradrenaline, 5-hydroxytryptamine, and histamine have been studied. The inhibitors antagonized depressions of spontaneously active neurones evoked by these amines, but not those evoked by gamma-aminobutyric acid, adenosine, adenosine 5'-monophosphate, or calcium. The antagonistic potencies of the various inhibitors appeared to be proportional to their known potencies as inhibitors of Na+, K+-ATPase.
CONCLUSIONS:
The data therefore support the hypothesis that amines depress central neurones by activating an electrogenic sodium pump.

Structure Identification:

J Pharm Biomed Anal. 1992 Jun;10(6):413-9.

Determination of thevetin B in serum by fluorescence polarization immunoassay.[Pubmed: 1420463]

METHODS AND RESULTS:
Thevetin B, a cardiac glycoside of Thevetia neriifolia Juss. seeds, was determined in serum by fluorescence polarization immunoassay. Anti-digitoxin antibody was used, Thevetin B genin being structurally identical to digitoxigenin.
CONCLUSIONS:
Cross-reactivity of 94% was found by this method, for concentrations from 5 to 80 ng ml-1.

Product Name	Thevetin B
Price:	$513 / 5mg
CAS No.:	27127-79-3
Catalog No.:	CFN96147
Molecular Formula:	C₄₂H₆₆O₁₈
Molecular Weight:	859.0 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Thevetia peruviana
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Cardiotonic Compound Library Steroids Compound Library Sodium Channel Inhibitor Library Potassium Channel Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1641 mL	5.8207 mL	11.6414 mL	23.2829 mL	29.1036 mL
5 mM	0.2328 mL	1.1641 mL	2.3283 mL	4.6566 mL	5.8207 mL
10 mM	0.1164 mL	0.5821 mL	1.1641 mL	2.3283 mL	2.9104 mL
50 mM	0.0233 mL	0.1164 mL	0.2328 mL	0.4657 mL	0.5821 mL
100 mM	0.0116 mL	0.0582 mL	0.1164 mL	0.2328 mL	0.291 mL

CFN98536	Digoxin	20830-75-5	780.94	C₄₁H₆₄O₁₄
CFN70364	Gitoxin	4562-36-1	781.0	C₄₁H₆₄O₁₄
CFN96658	Stauntosaponin A	1417887-91-2	486.60	C₂₈H₃₈O₇
CFN89202	Sarmentocymarin	98633-61-5	534.69	C₃₀H₄₆O₈
CFN89193	Cryptanoside A	98570-81-1	562.65	C₃₀H₄₂O₁₀
CFN97195	17alpha-Neriifolin	7044-31-7	534.7	C₃₀H₄₆O₈
CFN99868	Odoroside H	18810-25-8	534.7	C₃₀H₄₆O₈
CFN97718	Uzarigenin digitaloside	61217-80-9	534.69	C₃₀H₄₆O₈
CFN98691	Neritaloside	465-13-4	592.7	C₃₂H₄₈O₁₀
CFN98693	Oleandrin	465-16-7	576.7	C₃₂H₄₈O₉