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Toddacoumaquinone
Toddacoumaquinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Toddacoumaquinone
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CAS No.: 142878-03-3
Catalog No.: CFN92734
Molecular Formula: C23H18O7
Molecular Weight: 406.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The roots of Toddalia asiatica Lam.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Toddacoumaquinone shows a weak activity (EC50 = 10 micrograms/ml) against HSV-1 and HSV-2.
Targets: HSV
In vitro:
Chem Pharm Bull (Tokyo). 1995 Jun;43(6):1039-41.
Synthesis of toddacoumaquinone, a coumarin-naphthoquinone dimer, and its antiviral activities.[Pubmed: 7641303 ]

METHODS AND RESULTS:
Toddacoumaquinone (1), a coumarin-naphthoquinone dimer, was synthesized through Diels-Alder reaction between 8-(1-acetoxy-3-methyl-1,3-butadienyl)-5,7-dimethoxycoumarin (15) and 2-methoxy-1,4-benzoquinone (5). The activities of Toddacoumaquinone against several viruses were examined.
CONCLUSIONS:
A weak activity (EC50 = 10 micrograms/ml) was observed against HSV-1 and HSV-2, but no activity was seen against HIV-1.
Toddacoumaquinone Description
Source: The roots of Toddalia asiatica Lam.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4606 mL 12.3031 mL 24.6063 mL 49.2126 mL 61.5157 mL
5 mM 0.4921 mL 2.4606 mL 4.9213 mL 9.8425 mL 12.3031 mL
10 mM 0.2461 mL 1.2303 mL 2.4606 mL 4.9213 mL 6.1516 mL
50 mM 0.0492 mL 0.2461 mL 0.4921 mL 0.9843 mL 1.2303 mL
100 mM 0.0246 mL 0.123 mL 0.2461 mL 0.4921 mL 0.6152 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN925384,6-Dimethoxy-2H-1-benzopyran-2-one53666-78-7206.2C11H10O4
CFN970844,6,7-Trimethoxy-5-methylcoumarin62615-63-8250.3 C13H14O5
CFN96263Edgeworin120028-43-5322.3C18H10O6
CFN90329Daphnoretin2034-69-7352.3C19H12O7
CFN96604Isodaphnoretin B944824-29-7382.32C20H14O8
CFN95207Isoeuphorbetin50677-55-9354.3C18H10O8
CFN96473Triumbelletin131559-54-1482.39C27H14O9
CFN97913Mellein480-33-1178.2C10H10O3
CFN92734Toddacoumaquinone142878-03-3406.4C23H18O7
CFN89117Aflavarin144429-67-4454.43C24H22O9
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