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Tombozine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tombozine
Price:
CAS No.: 604-99-9
Catalog No.: CFN97028
Molecular Formula: C19H22N2O
Molecular Weight: 294.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Rauvolfia yunnanensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Tombozine is a natural product from Rauvolfia yunnanensis.
Tombozine Description
Source: The herbs of Rauvolfia yunnanensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3967 mL 16.9837 mL 33.9674 mL 67.9348 mL 84.9185 mL
5 mM 0.6793 mL 3.3967 mL 6.7935 mL 13.587 mL 16.9837 mL
10 mM 0.3397 mL 1.6984 mL 3.3967 mL 6.7935 mL 8.4918 mL
50 mM 0.0679 mL 0.3397 mL 0.6793 mL 1.3587 mL 1.6984 mL
100 mM 0.034 mL 0.1698 mL 0.3397 mL 0.6793 mL 0.8492 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemistry of Natural Compounds,2000 ,36 (5) :540-540
Alkaloids of Vinca minor[Reference: WebLink]
from the aerial part of the plant (3).
METHODS AND RESULTS:
We investigated alkaloids of the aerial part of V. minor cultivated in the Tashkent Botanical Garden during flowering. The aerial part (0.105 kg) was collected in June, 1997, wetted with aqueous ammonia (8%), left for 2 h, and extracted seven times with CHCl . Alkaloids were extracted from the condensed CHCl extracts by H SO (10%). The acid extract was 33 2 4 basicified with NaOH (10%) and extracted with CHCl . Then the alkaline solution was treated with ammonium chloride. The 3 phenolic part was extracted with CHCl . 3 The nonphenolic part (CHCl ) yielded 0.53 g; the phenolic part, 0.12 g. The overall yield was 0.65 g or 0.64% of the 3 dry weight. Column chromatography on silica gel of the nonphenolic part afforded vinc amine (3, 4), akuammicine (3, 5), reserpine (3, 6), majdine (3, 6), reserpinine (3, 6), vinerine (3, 6), ervine (3, 6), vineridine (3, 6), Tombozine (3, 6), vincamajine (3 , 6), and vincanine (3, 6). Column chromatography on silica gel of the phenolic part gave vincanidine (3, 6).
CONCLUSIONS:
All iso lated bases were identified by direct comparison of mixed melting points and IR and UV spectra with authentic samples. The last nine alkaloids were isolated for the first time from the examined species.
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