Trilobinine | CAS:126595-92-4 | Manufacturer ChemFaces

Trilobinine

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Description:

(+)-Trilobinine has relaxant effects via the activation of beta 2-adrenoceptors, it can reduce the spontaneous tone and inhibit the contractions induced by carbachol and histamine.

Targets:

Adrenergic Receptor

In vivo:

Planta Med. 1999 Jun;65(5):462-4.

Tracheal relaxant activity of cissaglaberrimine and trilobinine, two aporphinic alkaloids from Cissampelos glaberrima.[Pubmed: 10418339]

In the present work we studied the relaxant effect of two aporphinic alkaloids isolated from the roots barks of Cissampelos glaberrima St. Hil. (Menispermaceae), (+)-cissaglaberrimine (CGE; a tertiary alkaloid) and (+)-Trilobinine (TBE; a quaternary alkaloid).
METHODS AND RESULTS:
In guinea-pig tracheal preparations, CGE and TBE reduced the spontaneous tone and inhibited the contractions induced by carbachol and histamine. TBE was 6 times more potent than CGE in reducing the spontaneous tone and it was also 1.5 times more potent in antagonising the effects of carbachol and histamine. The inhibitory effect of CGE in contractions induced by histamine was not attenuated in the presence of timolol (10 microM). However, in the same experimental conditions, timolol almost completely abolished the inhibitory effect of TBE.
CONCLUSIONS:
These results showed that the relaxations induced by TBE were dependent on the activation of beta 2-adrenoceptors, while the mechanism involved in relaxations induced by CGE remains to be determined.

Trilobinine Description

Source:	The herbs of Cocculus orbiculatus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Trilobinine
Price:
CAS No.:	126595-92-4
Catalog No.:	CFN92948
Molecular Formula:	C₂₀H₂₄NO₄+
Molecular Weight:	342.41 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Cocculus orbiculatus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Adrenergic Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9205 mL	14.6024 mL	29.2048 mL	58.4095 mL	73.0119 mL
5 mM	0.5841 mL	2.9205 mL	5.841 mL	11.6819 mL	14.6024 mL
10 mM	0.292 mL	1.4602 mL	2.9205 mL	5.841 mL	7.3012 mL
50 mM	0.0584 mL	0.292 mL	0.5841 mL	1.1682 mL	1.4602 mL
100 mM	0.0292 mL	0.146 mL	0.292 mL	0.5841 mL	0.7301 mL

CFN95337	Fuzitine	142287-96-5	342.4	C₂₀H₂₄NO₄
CFN90259	Magnoflorine chloride	6681-18-1	377.87	C₂₀H₂₄NO₄Cl
CFN97169	Xanthoplanine	6872-88-4	356.4	C₂₁H₂₆NO₄
CFN97205	Laurifoline	7224-61-5	342.4	C₂₀H₂₄NO₄
CFN95594	4-Keto-laurifoline	N/A	356.4	C₂₀H₂₂NO₅+
CFN98071	Magnoflorine	2141-09-5	342.4	C₂₀H₂₄NO₄
CFN95318	Menisperine	25342-82-9	356.4	C₂₁H₂₆NO₄
CFN92891	N-Methylcorydinium iodide	4668-64-6	356.43	C₂₁H₂₆NO₄
CFN92948	Trilobinine	126595-92-4	342.41	C₂₀H₂₄NO₄+