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Tripalmitin
Tripalmitin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tripalmitin
Price: $30 / 20mg
CAS No.: 555-44-2
Catalog No.: CFN70139
Molecular Formula: C51H98O6
Molecular Weight: 807.3 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Oil
Source: The oil of Coconut.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Tripalmitin has additive effects on morphologies and tensile properties of polybutene-1 and its composite with micro fibrous cellulose.Tripalmitin can reduce significantly the development of tumors in experimental mice.
In vitro:
Diabetologia,2005,48:1819–1829.
Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro.[Reference: WebLink]
Long-term exposure of beta cells to lipids, particularly saturated fatty acids in vitro, results in cellular dysfunction and apoptosis (lipotoxicity); this could contribute to obesity-related diabetes. Our aims were to relate cell death to intracellular triglyceride concentration, composition and localisation following incubation of INS1 cells in saturated and unsaturated NEFA in high and low glucose concentrations.
METHODS AND RESULTS:
Insulin-producing INS1 cells were cultured (24 h; 3 and 20 mmol/l glucose) with palmitic, oleic or linoleic acids and the resulting intracellular lipids were analysed by gas chromatography and microscopy. Cell death was determined by quantitative microscopy and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and glucose-stimulated insulin secretion by ELISA. All NEFA (0.5 mmol/l, 0.5% albumin) inhibited glucose-stimulated (20 mmol/l) insulin secretion. Cytotoxicity was evident only with palmitic acid (p<0.05), in which case intracellular triglyceride consisted largely of Tripalmitin in angular-shaped dilated endoplasmic reticulum. Cytotoxicity and morphological disruption were reduced by addition of unsaturated NEFA. Triglyceride content (control cells; 14.5 ng/μg protein) increased up to 10-fold following incubation in NEFA (oleic acid 153.2 ng/μg protein; p<0.05) and triglyceride and phospholipid fractions were both enriched with the specific fatty acid added to the medium (p<0.05).
METHODS AND RESULTS:
In INS1 cells, palmitic acid is converted in the endoplasmic reticulum to solid Tripalmitin (melting point >65°C), which could induce endoplasmic reticulum stress proteins and signal apoptosis; lipid-induced apoptosis would therefore be a consequence of the physicochemical properties of these triglycerides. Since cellular triglycerides composed of single species of fatty acid are not likely to occur in vivo, destruction of beta cells by saturated fatty acids could be predominantly an in vitro scenario.
Polymer Bulletin, 2013, 70(4):1383-1395.
Additive effects of tripalmitin on morphologies and tensile properties of polybutene-1 and its composite with micro fibrous cellulose.[Reference: WebLink]
Morphologies and tensile properties of polybutene-1 (PB)/Tripalmitin (TP) blend and PB/micro fibrous cellulose (MFC)/TP composite were studied.
METHODS AND RESULTS:
The scanning electron microscope observation showed that the PB(70 %)/TP(30 %) had a microphase-separated structure. The DSC measurement showed that the crystallization of the PB part was affected by the TP existence. A new crystal structure was observed in the X-ray diffraction pattern of the PB(70 %)/TP(30 %). Quicker saturation of the PB crystal phase transformation from the metastable tetragonal (II) to the stable hexagonal (I) phase was observed in the PB(70 %)/TP(30 %) under the aging at r.t. The saturation controlled the Young’s modulus increment of the PB(70 %)/TP(30 %) in the aging process. The elongation at break value of the PB/TP increased by the loading of the TP, suggesting that the TP worked as the plasticizer.
CONCLUSIONS:
The thermogravimetry measurement of the PB(70 %)/TP(30 %) suggested that there existed an interaction between them. The TP addition provided a good dispersibility and ductility enhancement for PB/MFC composite. It was found that the TP worked as a good compatibilizer for the composite.
Tripalmitin Description
Source: The oil of Coconut.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2387 mL 6.1935 mL 12.387 mL 24.7739 mL 30.9674 mL
5 mM 0.2477 mL 1.2387 mL 2.4774 mL 4.9548 mL 6.1935 mL
10 mM 0.1239 mL 0.6193 mL 1.2387 mL 2.4774 mL 3.0967 mL
50 mM 0.0248 mL 0.1239 mL 0.2477 mL 0.4955 mL 0.6193 mL
100 mM 0.0124 mL 0.0619 mL 0.1239 mL 0.2477 mL 0.3097 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Philippine Journal of ence, 1994.
Effect of coconut oil, trilaurin and tripalmitin on the promotion stage of carcinogenesis.[Reference: WebLink]
Dimethylbenzanthracene, a polycyclic aromatic hydrocarbon, is a carcinogen. It interacts with DNA of the living cell through intercalation and alkylation. Thus it plays an important role in the initiation stage of carcinogenesis. Its activity with DNA can activate protooncogenes and inactive tumor suppressor genes.
METHODS AND RESULTS:
With dimethylbenzanthracene as an initiator and croton oil as a promoter, 100 percent of the experimental animals developed tumors within two weeks. Croton oil has phorbal esters which are well-known inducers of the promotion stage of carcinogenesis. The development of tumors was inhibited completely when coconut oil or trilaurin was applied with croton oil after initiation with dimethylbenzanthracene on the shaved skin of experimental mice. Trilaurin is the most predominant triacyl glycerol in coconut oil. Tripalmitin, another saturated fatty acyl glycerol in coconut oil, reduced significantly the development of tumors in experimental mice.
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