Tuberostemonine | CAS:6879-01-2 | Manufacturer ChemFaces

Tuberostemonine

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Description:

Tuberostemonine has antitussive activity, acts in part as an open-channel blocker at the crayfish neuromuscular junction; it also exhibits relatively higher intestinal permeabilities.

Targets:

Antifection

In vivo:

Planta Med. 2009 May;75(6):575-80.

Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa.[Pubmed: 19214944]

The intestinal absorption of four stereoisomers of Tuberostemonine-type alkaloids, neoTuberostemonine (1), Tuberostemonine (2), Tuberostemonine H (3), and Tuberostemonine J (4), isolated from the antitussive Chinese medicinal herb Radix Stemonae, and the IN VIVO antitussive activity of alkaloids 1, 2 and 3 were investigated in the current study.
METHODS AND RESULTS:
All three alkaloids exhibited dose-dependent inhibitory effects on citric acid-induced cough in guinea pigs after intraperitoneal administration. Alkaloid 2 had the same potency via both oral and intraperitoneal dosing, 1 exhibited significantly lower oral activity than that following intraperitoneal application, while 3 did not show oral activity.
CONCLUSIONS:
Alkaloid 4 demonstrated a moderate permeability in Caco-2 monolayer cells while alkaloids 1, 2 and 3 exhibited relatively higher intestinal permeabilities, indicating that all four alkaloids tested had reasonable oral absorption.

Tuberostemonine Description

Source:	The roots of Stemona japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Brain Res. 1985 May 13;334(1):33-40.

Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction.[Pubmed: 2581668]

METHODS AND RESULTS:
At the crayfish neuromuscular junction, Tuberostemonine, an alkaloid from Stemona japonica, reduced the amplitude of both the excitatory junctional potential (e.j.p.) and the glutamate response in a dose-dependent manner at concentrations above 0.1 mM. Tuberostemonine acted presynaptically on the crayfish neuromuscular junction to reduce a quantal content of extracellularly recorded e.j.p.s, and postsynaptically to reduce their unit size. The decay of the excitatory synaptic current was accelerated by Tuberostemonine. The gradual decline of the successive glutamate currents induced by a train was facilitated by the presence of Tuberostemonine even in the muscle fibre pre-treated with concanavalin A. The rate of recovery from the refractory form of the glutamate receptor to the free reactive one was slightly affected by Tuberostemonine when it was determined by using a paired pulse method. The inhibitory action of Tuberostemonine on glutamate responses was voltage-dependent and hyperpolarization increased the drug action.
CONCLUSIONS:
These results indicate that Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.

Product Name	Tuberostemonine
Price:	$148 / 20mg
CAS No.:	6879-01-2
Catalog No.:	CFN98138
Molecular Formula:	C₂₂H₃₃NO₄
Molecular Weight:	375.51 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Stemona japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Nematicidal Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.663 mL	13.3152 mL	26.6304 mL	53.2609 mL	66.5761 mL
5 mM	0.5326 mL	2.663 mL	5.3261 mL	10.6522 mL	13.3152 mL
10 mM	0.2663 mL	1.3315 mL	2.663 mL	5.3261 mL	6.6576 mL
50 mM	0.0533 mL	0.2663 mL	0.5326 mL	1.0652 mL	1.3315 mL
100 mM	0.0266 mL	0.1332 mL	0.2663 mL	0.5326 mL	0.6658 mL

CFN98725	Neostenine	477953-07-4	277.4	C₁₇H₂₇NO₂
CFN97497	Sessilifoline A	929637-35-4	389.5	C₂₂H₃₁NO₅
CFN97534	Neotuberostemonone	954379-68-1	405.5	C₂₂H₃₁NO₆
CFN98138	Tuberostemonine	6879-01-2	375.51	C₂₂H₃₃NO₄
CFN99475	Neotuberostemonine	143120-46-1	375.5	C₂₂H₃₃NO₄
CFN96768	Bisdehydroneotuberostemonine	160333-27-7	371.47	C₂₂H₂₉NO₄
CFN80139	Protostemonine	27495-40-5	417.21	C₂₃H₃₁NO₆