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Vibralactone D
Vibralactone D
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Vibralactone D
Price:
CAS No.: 1251748-32-9
Catalog No.: CFN96454
Molecular Formula: C12H18O3
Molecular Weight: 210.27 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: From Boreostereum vibrans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Vibralactones D shows weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
Vibralactone D Description
Source: From Boreostereum vibrans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7558 mL 23.779 mL 47.5579 mL 95.1158 mL 118.8948 mL
5 mM 0.9512 mL 4.7558 mL 9.5116 mL 19.0232 mL 23.779 mL
10 mM 0.4756 mL 2.3779 mL 4.7558 mL 9.5116 mL 11.8895 mL
50 mM 0.0951 mL 0.4756 mL 0.9512 mL 1.9023 mL 2.3779 mL
100 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1889 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Chem Pharm Bull (Tokyo). 2010 Jan;58(1):113-6.
Vibralactones D-F from cultures of the basidiomycete Boreostereum vibrans.[Pubmed: 20045978]
Three new metabolites, Vibralactone D, vibralactone E, vibralactone F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans.
METHODS AND RESULTS:
The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
CFN89224Bisabola-3,10-dien-2-one61432-71-1220.35C15H24O
CFN969951-Hydroxybisabola-2,10-dien-4-one1213251-45-6236.35C15H24O2
CFN892444-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one170380-68-4220.31C14H20O2
CFN975129-Oxo-2,7-bisaboladien-15-oic acid93888-59-6250.3 C15H22O3
CFN963714-Hydroxy-1,10-secocadin-5-ene-1,10-dione226904-40-1252.4C15H24O3
CFN91876Bisabolangelone30557-81-4248.32C15H20O3
CFN892673,4-Seco-3-oxobisabol-10-ene-4,1-olide1564265-85-5252.35C15H24O3
CFN99670Catalpalactone1585-68-8258.3 C15H14O4
CFN99782Fraxinellone28808-62-0232.28C14H16O3
CFN96832Dasycarpol202343-57-5248.27C14H16O4
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