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Vindolinine
Vindolinine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Vindolinine
Price: $413 / 5mg
CAS No.: 5980-02-9
Catalog No.: CFN90926
Molecular Formula: C21H24N2O2
Molecular Weight: 336.43 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The leaves of Catharanthus roseus (L.) G. Don.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $321.3 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Vindolinine is a natural product from Catharanthus roseus (L.) G. Don.
In vitro:
Fitoterapia. 2015 Apr;102:182-8.
Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).[Pubmed: 25665941 ]

METHODS AND RESULTS:
Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, Vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and β-TC6 mouse pancreatic cells (IC50>50μg/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200μg/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro α-amylase and α-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine.
CONCLUSIONS:
This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.
Vindolinine Description
Source: The leaves of Catharanthus roseus (L.) G. Don.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9724 mL 14.8619 mL 29.7239 mL 59.4477 mL 74.3097 mL
5 mM 0.5945 mL 2.9724 mL 5.9448 mL 11.8895 mL 14.8619 mL
10 mM 0.2972 mL 1.4862 mL 2.9724 mL 5.9448 mL 7.431 mL
50 mM 0.0594 mL 0.2972 mL 0.5945 mL 1.189 mL 1.4862 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.5945 mL 0.7431 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN98256Scandine24314-59-8350.4 C21H22N2O3
CFN89217Scandine Nb-oxide140701-69-5366.41C21H22N2O4
CFN9673010-Acetoxyscandine1432058-90-6408.45C23H24N2O5
CFN96116Tubotaiwine6711-69-9324.4C20H24N2O2
CFN89178Hecubine62874-52-6310.44C20H26N2O
CFN97570Scholaricine99694-90-3356.4 C20H24N2O4
CFN9820511-Hydroxytabersonine22149-28-6352.4 C21H24N2O3
CFN98338Ervamycine27773-39-3366.5 C22H26N2O3
CFN89194Echitovenidine7222-35-7436.55C26H32N2O4
CFN89203Echitoveniline72855-79-9548.63C31H36N2O7
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