Vindolinine | CAS:5980-02-9 | Manufacturer ChemFaces

Vindolinine

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Description:

Vindolinine is a natural product from Catharanthus roseus (L.) G. Don.

In vitro:

Fitoterapia. 2015 Apr;102:182-8.

Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).[Pubmed: 25665941 ]

METHODS AND RESULTS:
Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, Vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and β-TC6 mouse pancreatic cells (IC50>50μg/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200μg/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro α-amylase and α-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine.
CONCLUSIONS:
This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.

Vindolinine Description

Source:	The leaves of Catharanthus roseus (L.) G. Don.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vindolinine
Price:	$413 / 5mg
CAS No.:	5980-02-9
Catalog No.:	CFN90926
Molecular Formula:	C₂₁H₂₄N₂O₂
Molecular Weight:	336.43 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The leaves of Catharanthus roseus (L.) G. Don.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9724 mL	14.8619 mL	29.7239 mL	59.4477 mL	74.3097 mL
5 mM	0.5945 mL	2.9724 mL	5.9448 mL	11.8895 mL	14.8619 mL
10 mM	0.2972 mL	1.4862 mL	2.9724 mL	5.9448 mL	7.431 mL
50 mM	0.0594 mL	0.2972 mL	0.5945 mL	1.189 mL	1.4862 mL
100 mM	0.0297 mL	0.1486 mL	0.2972 mL	0.5945 mL	0.7431 mL

CFN98205	11-Hydroxytabersonine	22149-28-6	352.4	C₂₁H₂₄N₂O₃
CFN98338	Ervamycine	27773-39-3	366.5	C₂₂H₂₆N₂O₃
CFN89194	Echitovenidine	7222-35-7	436.55	C₂₆H₃₂N₂O₄
CFN89203	Echitoveniline	72855-79-9	548.63	C₃₁H₃₆N₂O₇
CFN98799	Vandrikidine	50656-92-3	382.5	C₂₂H₂₆N₂O₄
CFN98853	Vindorosine	5231-60-7	426.5	C₂₄H₃₀N₂O₅
CFN98083	Vindoline	2182-14-1	456.5	C₂₅H₃₂N₂O₆
CFN90926	Vindolinine	5980-02-9	336.43	C₂₁H₂₄N₂O₂
CFN98256	Scandine	24314-59-8	350.4	C₂₁H₂₂N₂O₃
CFN89217	Scandine Nb-oxide	140701-69-5	366.41	C₂₁H₂₂N₂O₄