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Vinorine
Vinorine
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Product Name Vinorine
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CAS No.: 34020-07-0
Catalog No.: CFN97757
Molecular Formula: C21H22N2O2
Molecular Weight: 334.42 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Rauvolfia serpentina
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.
Vinorine Description
Source: The roots of Rauvolfia serpentina
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9903 mL 14.9513 mL 29.9025 mL 59.805 mL 74.7563 mL
5 mM 0.5981 mL 2.9903 mL 5.9805 mL 11.961 mL 14.9513 mL
10 mM 0.299 mL 1.4951 mL 2.9903 mL 5.9805 mL 7.4756 mL
50 mM 0.0598 mL 0.299 mL 0.5981 mL 1.1961 mL 1.4951 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.5981 mL 0.7476 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorg Med Chem. 2004 May 15;12(10):2787-95.
Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase.[Pubmed: 15110860]
Vinorine synthase (EC 2.3.1.160) catalyses the acetyl-CoA- or CoA-dependent reversible formation of the alkaloids Vinorine (or 11-methoxy-Vinorine) and 16-epi-vellosimine (or gardneral). The forward reaction leads to Vinorine, which is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.
METHODS AND RESULTS:
Based on partial peptide sequences a cDNA clone was isolated and functionally expressed in Escherichia coli. The Km values of the native enzyme for gardneral and acetyl-CoA were determined to be 7.5 and 57 microM. The amino acid sequence of Vinorine synthase has highest level of identity (28-31%) to that of Papaver salutaridinol acetyltransferase, Fragaria alcohol acyltransferase, and Catharanthus deacetylvindoline acetyltransferase involved in morphine, flavor, and vindoline biosynthesis, respectively. Vinorine synthase is a novel member of the BAHD superfamily of acyltransferases. Site-directed mutagenesis of 13 amino acid residues provided clear evidence that both, His160 and Asp164 of the consensus sequence HxxxD belong to the catalytic center. The mutations also showed that an amino acid triad is not characteristic of Vinorine synthase.
CONCLUSIONS:
The experiments demonstrated the importance of the conserved motif SxL/I/VD near the N-terminus and the consensus sequence DFGWG near the C-terminal.
CFN97910Alstoyunine E1188932-15-1350.4C21H22N2O3
CFN97762Raucaffricine31282-07-2512.56C27H32N2O8
CFN98673Perakine4382-56-3350.4 C21H22N2O3
CFN92509(+)-Isoajmaline6989-79-3326.4C20H26N2O2
CFN93513Ajmaline4360-12-7326.4C20H26N2O2
CFN92581Ajmalidine639-30-5324.4C20H24N2O2
CFN92611Ajmalan-17-one3911-19-1322.4C20H22N2O2
CFN92503Ajmalimine59846-31-0520.6C30H36N2O6
CFN92504Rauvomitin466-57-9502.6C30H34N2O5
CFN96749Rauvotetraphylline D1422506-52-2390.48C24H26N2O3
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