Vinorine | CAS:34020-07-0 | Manufacturer ChemFaces

Vinorine

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Vinorine Description

Source:	The roots of Rauvolfia serpentina
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Bioorg Med Chem. 2004 May 15;12(10):2787-95.

Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase.[Pubmed: 15110860]

Vinorine synthase (EC 2.3.1.160) catalyses the acetyl-CoA- or CoA-dependent reversible formation of the alkaloids Vinorine (or 11-methoxy-Vinorine) and 16-epi-vellosimine (or gardneral). The forward reaction leads to Vinorine, which is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.
METHODS AND RESULTS:
Based on partial peptide sequences a cDNA clone was isolated and functionally expressed in Escherichia coli. The Km values of the native enzyme for gardneral and acetyl-CoA were determined to be 7.5 and 57 microM. The amino acid sequence of Vinorine synthase has highest level of identity (28-31%) to that of Papaver salutaridinol acetyltransferase, Fragaria alcohol acyltransferase, and Catharanthus deacetylvindoline acetyltransferase involved in morphine, flavor, and vindoline biosynthesis, respectively. Vinorine synthase is a novel member of the BAHD superfamily of acyltransferases. Site-directed mutagenesis of 13 amino acid residues provided clear evidence that both, His160 and Asp164 of the consensus sequence HxxxD belong to the catalytic center. The mutations also showed that an amino acid triad is not characteristic of Vinorine synthase.
CONCLUSIONS:
The experiments demonstrated the importance of the conserved motif SxL/I/VD near the N-terminus and the consensus sequence DFGWG near the C-terminal.

Product Name	Vinorine
Price:
CAS No.:	34020-07-0
Catalog No.:	CFN97757
Molecular Formula:	C₂₁H₂₂N₂O₂
Molecular Weight:	334.42 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Rauvolfia serpentina
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Precursors Compound Library Antiarrhythmic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9903 mL	14.9513 mL	29.9025 mL	59.805 mL	74.7563 mL
5 mM	0.5981 mL	2.9903 mL	5.9805 mL	11.961 mL	14.9513 mL
10 mM	0.299 mL	1.4951 mL	2.9903 mL	5.9805 mL	7.4756 mL
50 mM	0.0598 mL	0.299 mL	0.5981 mL	1.1961 mL	1.4951 mL
100 mM	0.0299 mL	0.1495 mL	0.299 mL	0.5981 mL	0.7476 mL

CFN98673	Perakine	4382-56-3	350.4	C₂₁H₂₂N₂O₃
CFN92509	(+)-Isoajmaline	6989-79-3	326.4	C₂₀H₂₆N₂O₂
CFN93513	Ajmaline	4360-12-7	326.4	C₂₀H₂₆N₂O₂
CFN92581	Ajmalidine	639-30-5	324.4	C₂₀H₂₄N₂O₂
CFN92611	Ajmalan-17-one	3911-19-1	322.4	C₂₀H₂₂N₂O₂
CFN92503	Ajmalimine	59846-31-0	520.6	C₃₀H₃₆N₂O₆
CFN92504	Rauvomitin	466-57-9	502.6	C₃₀H₃₄N₂O₅
CFN96749	Rauvotetraphylline D	1422506-52-2	390.48	C₂₄H₂₆N₂O₃
CFN97757	Vinorine	34020-07-0	334.42	C₂₁H₂₂N₂O₂
CFN97910	Alstoyunine E	1188932-15-1	350.4	C₂₁H₂₂N₂O₃