Wilfortrine | CAS:37239-48-8 | Manufacturer ChemFaces

Wilfortrine

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression. The combined treatment using wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug. Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) show marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices.

Targets:

Bcl-2/Bax | Immunology & Inflammation related

In vitro:

Genet Mol Res. 2015 Nov 30;14(4):15349-55.

Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro.[Pubmed: 26634500 ]

Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether Wilfortrine can induce liver cancer cell apoptosis has not been elucidated.
METHODS AND RESULTS:
We investigated the role of Wilfortrine on liver cancer cell HepG2 apoptosis and analyzed its possible mechanisms to provide a theoretical basis for clinical analysis of liver cancer pathogenesis. The liver cancer cell line HepG2 was treated with 40 mM Wilfortrine for 48 h. Flow cytometry was applied to detect HepG2 cell apoptosis and cell cycle changes. Western blot was used to analyze Bcl-2 and Bax expression. The HepG2 cell apoptosis rate increased significantly after treatment with Wilfortrine, especially the early apoptosis rate (P < 0.05). However, Wilfortrine did not change the cell cycle of HepG2 cells. After Wilfortrine treatment, Bcl- 2 expression decreased significantly (P < 0.05); on the contrary, Bax expression increased noticeably compared with the control group (P < 0.05).
CONCLUSIONS:
Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression.

In vivo:

Yao Xue Xue Bao. 1989;24(8):568-72.

Immunosuppresive effects of wilfortrine and euonine.[Pubmed: 2618700]

Wifortrine and Euonine isolated from Tripterygium wilfordii Hook. f.
METHODS AND RESULTS:
Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) showed marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. Wilfortrine (160 mg/kg.d x 9d ip) exhibited a depressant effect on graft vs host reaction (GVHR), but Wilfortrine (80 mg/(kg.d) x 9d ip) showed no definite effect. Euonine (80 mg/(kg.d) x 10d ip) showed marked suppressant effects on DNCB induced delayed hypersensitivity reaction on skin in mice. Wilfortrine and Euonine (80 mg/(kg.d) x 4d ip) significantly decreased the clearance rate of charcoal particles and the weights of spleen and thymus.

Wilfortrine Description

Source:	The roots of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Med Sci Monit. 2016 Apr 4;22:1109-14.

Effect of Combined Treatment Using Wilfortrine and Paclitaxel in Liver Cancer and Related Mechanism.[Pubmed: 27043783 ]

Liver cancer is a common malignant tumor with high mortality. Currently, effective medicines against liver cancer are still lacking. Paclitaxel is a wide-spectrum anti-tumor agent, while Wilfortrine has been shown to have an inhibitory effect on the proliferation of liver cancer cells. This study thus investigated the potential effect of paclitaxel combined with Wilfortrine on cultured liver cancer cells and related mechanisms, in order to provide evidence for pathogenesis and treatment of liver cancer.
METHODS AND RESULTS:
Liver cancer cell line HpeG2 was divided into control, paclitaxel, Wilfortrine, and combined treatment groups. Cell proliferation was tested by MTT, while invasion was detected in Transwell chamber assay. Apoptotic protein Bcl-2 and Bax expression levels were further quantified using real-time PCR and Western blotting. Both of those 2 drugs can effectively inhibit cancer cell proliferation, depress invasion ability, increase Bcl-2 expression, and elevate Bax expression levels (p<0.05 in all cases). The combined therapy had better treatment efficacy compared to either of those drugs alone (p<0.05).
CONCLUSIONS:
The combined treatment using Wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug.

Product Name	Wilfortrine
Price:
CAS No.:	37239-48-8
Catalog No.:	CFN92105
Molecular Formula:	C₄₁H₄₇NO₂₀
Molecular Weight:	873.8 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Pro-apoptotic Compound Library Anti-invasion Compound Library Immunosuppression Compound Library Sesquiterpenoids Compound Library Immunology & Inflammation related Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1444 mL	5.7221 mL	11.4443 mL	22.8885 mL	28.6107 mL
5 mM	0.2289 mL	1.1444 mL	2.2889 mL	4.5777 mL	5.7221 mL
10 mM	0.1144 mL	0.5722 mL	1.1444 mL	2.2889 mL	2.8611 mL
50 mM	0.0229 mL	0.1144 mL	0.2289 mL	0.4578 mL	0.5722 mL
100 mM	0.0114 mL	0.0572 mL	0.1144 mL	0.2289 mL	0.2861 mL

CFN92115	Regelidine	114542-54-0	599.7	C₃₅H₃₇NO₈
CFN92102	Evonimine	41758-69-4	805.8	C₃₈H₄₇NO₁₈
CFN92117	Aquifoliunine E-III	220751-20-2	763.8	C₃₆H₄₅NO₁₇
CFN92107	Evonine	33458-82-1	805.8	C₃₈H₄₇NO₁₈
CFN92106	Hypoglaunine A	228259-16-3	873.8	C₄₁H₄₇NO₂₀
CFN92105	Wilfortrine	37239-48-8	873.8	C₄₁H₄₇NO₂₀
CFN98605	Wilforgine	37239-47-7	857.8	C₄₁H₄₇NO₁₉
CFN92116	Triptonine B	168009-85-6	967.9	C₄₆H₄₉NO₂₂