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Zanthobungeanine
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Product Name Zanthobungeanine
Price: $318 / 20mg
CAS No.: 64190-94-9
Catalog No.: CFN96395
Molecular Formula: C16H17NO3
Molecular Weight: 271.3 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Zanthoxylum nitidum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $94.0 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.It shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). Zanthobungeanine shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell.
Targets: NO | PAFR
In vitro:
Anti-tumor Pharmacy, 2011,1(1) :30-2.
Inhibitory action of nitidine and zanthobungeanine on lung adenocarcinoma A549 cell[Reference: WebLink]
To determine the inhibition of nitidine and Zanthobungeanine on the lung adenocarcinoma A549 cell.
METHODS AND RESULTS:
The IC50 of nitidine and Zanthobungeanine were evaluated by MTT photocolorimetric method and the apoptosis was evaluated by inverted microscope. The IC_(50) of nitidine was 0.68μg·mL~(-1) and the IC_(50) of Zanthobungeanine was 173.41μg·mL~(-1).The nitidine 1.015μg·mL~(-1) induced apoptosis of 66%of lung adenocarcinoma A549 cells.The typical apoptic morphological changes,including cell shrinkage,nuclear condensation,and nuclear fragment was observed under light microscope.
CONCLUSIONS:
Nitidine can kill the external A549 cell and inhibit the development of A549 cell,but Zanthobungeanine showed the inhibitory action only in high concentration and had no antipersonnel effect on A549 cell.Nitidine can inhibit the proliferation of lung adenocarcinoma A549 cell by inducing apoptosis.Zanthobungeanine didn't show such action.
Journal of Shenyang Pharmaceutical University, 2013,30(2) :100-5.
Isolation,identification and activity determination on the anti-inflammatory components of roots of Zanthoxylum nitidum[Reference: WebLink]
To study the chemical constituents of Zanthoxylum nitidum(Roxb.)DC.and find compounds with anti-inflammatory activity.
METHODS AND RESULTS:
Silica gel column chromatography,RP-ODS,Sephadex LH-20 and high performance liquid chromatography were applied for the isolation and purification of the constituents.The structures were elucidated by their physicochemical properties and spectral methods.,The inhibitory activity on NO production and cell survival was evaluated by MTT assay through measuring the absorbance using microplate reader. Thirteen compounds were isolated,including skimmianine(1),dictamnine(2),Zanthobungeanine(3),zanthodioline(4),N-methylflindersine(5),liriodenine(6),L-sesamin(7),β-amyrin(8),stigmast-9(11)-en-3-ol(9),tridecane amine(10),tetradecane amine(11),heptadecanoic amine(12)and nonadecane amine(13).
CONCLUSIONS:
Compounds 3,4,8,10,11,12 and 13 are all isolated from Zanthoxylum nitidum for the first time.Compound 3 shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg · L-1.
Zanthobungeanine Description
Source: The roots of Zanthoxylum nitidum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.686 mL 18.4298 mL 36.8596 mL 73.7191 mL 92.1489 mL
5 mM 0.7372 mL 3.686 mL 7.3719 mL 14.7438 mL 18.4298 mL
10 mM 0.3686 mL 1.843 mL 3.686 mL 7.3719 mL 9.2149 mL
50 mM 0.0737 mL 0.3686 mL 0.7372 mL 1.4744 mL 1.843 mL
100 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.7372 mL 0.9215 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Plant Resources & Environment, 1993,2(2):25-7.
The active constituents of platelet-activating factor (PAF) inhibitors from Zanthoxylum planispinum Sieb. et Zucc[Reference: WebLink]

METHODS AND RESULTS:
Five compounds were isolated from the petroleum ether and methylene chloride extracts of the roots and stems of Zanthoxylum planispinum Sieb. et Zucc. (Rutaceae). The structure of these compounds were determined on the basis of physical constant and UV, IR, ~1HNMR, MS spectral analysis. They are β-amyrin ( I ) , β-sitosterol ( Ⅱ ) , L-asarinin ( I ) , L-planinin ( IV ) and Zanthobungeanine ( V ) respectively.
CONCLUSIONS:
Compound I 、 IV 、 V showed obviously inhibitoryactivity to platelet aggregation caused by PAF, among them compound Ⅲ was less active than compound V , compound V was the least. Zanthobungeanine was isolated for the first time from this plant.
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