alpha-Dihydroartemisinin | CAS:81496-81-3

alpha-Dihydroartemisinin

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alpha-Dihydroartemisinin Description

Source:	The herbs of Artemisia annua L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):180-91.

On-column epimerization of dihydroartemisinin: an effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph.[Pubmed: 18617445]

We developed a cryo-HPLC/UV method for the simultaneous determination of artemisinin (1), alpha-Dihydroartemisinin (2alpha), beta-dihydroartemisinin (2beta), and a ubiquitous thermal decomposition product of 2 (designated as diketoaldehyde, 3), starting from the International Pharmacopoeia monograph on dihydroartemisinin. The method takes for the first time the on-column epimerization process of 2 into consideration. Chromatographic separation was obtained under reversed-phase conditions on a Symmetry C18 column (3.5 microm particle size) with a mobile phase consisting of acetonitrile-water 60:40 (v/v), delivered at 0.60-1.00 ml/min flow-rates, with ultraviolet detection at low wavelength (lambda = 210 nm).
CONCLUSIONS:
Low temperatures (T = 0-10 degrees C) were selected on the grounds of a diastereoselective dynamic HPLC (DHPLC) study performed at different temperatures, aimed at identifying the best experimental conditions capable of minimizing the on-column interconversion process.

Product Name	alpha-Dihydroartemisinin
Price:	$60 / 20mg
CAS No.:	81496-81-3
Catalog No.:	CFN90485
Molecular Formula:	C₁₅H₂₄O₅
Molecular Weight:	284.34 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Cryst.
Source:	The herbs of Artemisia annua L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library Antifection Inhibitor Library

Description:	Dihydroartemisinin is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs, is recommended as the first-line anti-malarial drug with low toxicity. Dihydroartemisinin possesses promising anticancer activities and induce cancer cell death through apoptotic pathways.
Targets:	Antifection

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5169 mL	17.5846 mL	35.1692 mL	70.3383 mL	87.9229 mL
5 mM	0.7034 mL	3.5169 mL	7.0338 mL	14.0677 mL	17.5846 mL
10 mM	0.3517 mL	1.7585 mL	3.5169 mL	7.0338 mL	8.7923 mL
50 mM	0.0703 mL	0.3517 mL	0.7034 mL	1.4068 mL	1.7585 mL
100 mM	0.0352 mL	0.1758 mL	0.3517 mL	0.7034 mL	0.8792 mL

CFN97212	Deoxyartemisinin	72826-63-2	266.3	C₁₅H₂₂O₄
CFN99507	Dihydroartemisinin	71939-50-9	284.35	C₁₅H₂₄O₅
CFN99184	Artemether	71963-77-4	298.38	C₁₆H₂₆O₅
CFN99011	Artemisinin	63968-64-9	282.3	C₁₅H₂₂O₅
CFN90485	alpha-Dihydroartemisinin	81496-81-3	284.34	C₁₅H₂₄O₅
CFN90313	Artesunate	88495-63-0	384.42	C₁₉H₂₈O₈