Screening Libraries
| Cat. | Size | Price | Stock | |
| T10099 | 1mg/well * 24 Compounds | Inquiry | In stock | Contact Us |
| T10099 | 100uL/well (10mM solution) * 24 Compounds | Inquiry | In stock |
| manager@chemfaces.com | |
| Tel | (0086)-27-8423-7683 |
| Shelf Life | (0086)-27-84254680 |
| Manufacturer | Wuhan ChemFaces Biochemical Co., Ltd. |
| Container | 96 Well Format Sample |
| Storage | Protected from air and light, refrigerate or freeze(2-8 °) |
| Shelf Life | 24 months (2-8 °) |
| Intended Use | For research use only. Not for human use. Not sell to patients |
| 1. The products in the ChemFaces screening libraries are all from plants. |
| 2. The biological activities or pharmacological activities of all the ChemFaces products are derived from the databases of all over the world the latest literatures, you can according to the product manuals on our website to access the relevant literatures, hope that our informations can give some inspirations and help to your research. |
| 3.The collections of unique natural products, which include antioxidants, anti-inflammatory, antibacterial, anticancer, and ect. Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools. |
| 4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity. |
| 5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution). |
| Catalog No. | Information |
| CFN99621 | Marmin Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine. It can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels. Marmin shows a cell-growth inhibitory effect against L1210 and K562 in vitro.S-trans-Marmin shows potent antibacterial, fungicidal, and algicidal properties. Marmin, skimmianine, aegeline, aurapten, zeorin, and dustanin are potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor. |
| CFN99710 | Wogonoside Wogonoside has anticoagulant, anti-inflammatory, anti-angiogenic and anticancer effects, it may exert its anti-inflammatory effect via dual inhibition of NF-κB and NLRP3 inflammasome. Wogonoside induced autophagy through the MAPK-mTOR pathway, it inhibited LTB 4 production at the concentration of 100 uM. |
| CFN99859 | Corchoionoside C Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction. |
| CFN98030 | (-)-Maackiain (-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene. It shows significant growth inhibitory action on the growth of the human lymphoblastoid cell lines Molt and Raji, and shows a strong larvicidal effect against 4th instar larvae of Aedes aegypti(LC50=21.95±1.34ug/mL). |
| CFN98222 | Zeorin Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release. |
| CFN98172 | Vitexicarpin Vitexicarpin has shown antitumor, cytotoxicity, anti-inflammatory, analgesic and immunoregulatory properties.Vitexicarpin can act as a novel angiogenesis inhibitor, it exerts good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor-(VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner. It can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. |
| CFN98653 | Lacinilene C Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through potential-dependent channels of smooth muscle cell membranes. |
| CFN90005 | Fingolimod hydrochloride Fingolimod hydrochloride is an oral sphingosine-1-phosphate analogue that was approved by the FDA in 2010 for the treatment of relapsing forms of multiple sclerosis (MS). Fingolimod hydrochloride , a pak1 activator, can inhibit astemizole-induced hypertrophy and cytotoxicity in H9c2 cells, suggests that antihistamine-induced cardiac adverse effects are associated with pak1 expression and function.The gels containing 0.50% fingolimod hydrochloride (FNGL) and FNGL 0.50% plus 6% colloidal oatmeal have potential for the treatment of atopic dermatitis (AD). |
| CFN98690 | Arjunolic acid Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.Arjunolic acid protects cardiac tissues from both extrinsic and intrinsic cell death pathways.Arjunolic acid exhibits better protection against histamine release than against acetylcholine release, anti-asthmatic and anaphylactic activity of it may be possibly due to membrane stabilizing potential and inhibition of antigen induced histamine and acetylcholine release. Arjunolic acid protects cardiac tissues from both extrinsic and intrinsic cell death pathways, it also has antitumor activity. |
| CFN90029 | Histamine Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist. Histamine increases Nav1.8 expression in primary afferent neurons via H2 receptor-mediated pathway and thereby contributes to neuropathic pain, H2 receptor antagonists may potentially be used as analgesics for patients with neuropathic pain. |
