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  • Chrysophanol

    Chrysophanol has anti-inflammatory activity through the suppression of NF-κB/caspase-1 activation in vitro and in vivo.[1] Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.[2] Chrysophanol has mild cytotoxicity and ant...
  • Ellagic acid

    Ellagic acid, a naturally occurring plant phenol, inhibits the activity of the direct-acting mutagen N-methyl-N-nitrosourea (MeNU) in Salmonella typhimurium TA100, is due to specific inhibition of methylation at the O6 position of guanine through an ellagic acid-duplex DNA affinity-binding m...
  • Hyperoside

    Hyperoside, a flavonoid glycoside isolated from Artemisia capillaris, has protective effects against CCl4-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.[1] Hyperoside can protect A&bet...
  • Isoimperatorin

    Isoimperatorin is a medicinal herbal product that is isolated from the dried roots of Angelicae dahuricae ,can inhibit the cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D 2 (PGD 2 ) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner, wit...
  • Procyanidin C1

    In vitro, procyanidin C1 (PC1) dose-dependently decreased Fc epsilon RI-mediated degranulation and cytokine production of mast cells, inhibited tyrosine phosphorylation of Syk and linker for activation of T cells, and the ROS generation in stimulated mast cells.PC1 suppresses Fc epsilon RI-m...
  • Arctigenin

    Arctigenin, naturally occurring in Bardanae fructus, Saussurea medusa, Arctium lappa L., Torreya nucifera and Ipomea cairica, is a phenylpropanoid dibenzylbutyrolactone lignan with antioxidant and anti-inflammatory activities, it can potently inhibit the activity of MKK1 in vitro with the IC...
  • Ferulic acid

    Ferulic acid is the most abundant hydroxycinnamic acid in the plant world and maize bran with 3.1% (w/w) ferulic acid, is an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications, shows antioxidant activity in parallel with thei...
  • 6-Shogaol

    6-Shogaol, an active constituent of ginger, is a potent inhibitor of MDA-MB-231 cell invasion, and the molecular mechanism involves at least in part the down-regulation of MMP-9 transcription by targeting the NF-κB activation cascade, thus has potential for clinical use as antimetastatic tr...
  • Aloeemodin

    Aloeemodin is able to interact with DNA under certain in vitro conditions, however, in vivo it is negative did not indicate a genotoxic potential, thus, it may be assumed that a genotoxic risk for man might be unlikely.[1] Aloeemodin has inhibition of β-amyloid aggregation, and ha...
  • Imperatorin

    Imperatorin, a biologically active furanocoumarin from the roots of Angelica dahurica (Umbelliferae), can induce apoptosis in human promyelocytic leukaemia, HL-60 cells, and induces apoptosis was significantly blocked by Z-VAD-FMK (a broad spectrum caspase inhibitor), Z-LEHD-FMK (a caspase-9 inh...
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