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  • Prim-O-glucosylcimifugin

    Prim-O-glucosylcimifugin is main medicinal component of the traditional Chinese drug Saposhnikovia divaricata, can increase concentrations of astragaloside IV and atractylenolide I in the serum, when they were given together.[1] Prim-O-glucosylcimifugin has inhibition on NO production and D...
  • Platycodin D

    Platycodon D (PD) and D3 (PD3) isolated from Platycodon grandiflorum has been previously reported to show anti-inflammatory activities in rats, PD may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, suggest a dichotomous regulation of these important proinflammato...
  • Byakangelicin

    Byakangelicin is found in extracts of the root of Angelica dahurica, used in Korea and China as a traditional medicine to treat colds, headache and toothache, it can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones, it induces cytochrome P450 3A4 expressi...
  • 20(R)-Ginsenoside Rg3

    20(R)-Ginsenoside Rg3 has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment, however, 20(R)-Ginsenoside Rg3 has a low bioavailability after oral administration in human, so, 20(R)-Rg3 can be by intranasal administration, th...
  • Catalpol

    Catalpol, an iridoid glucoside, has been reported to inhibit apoptosis of neuron and endothelial cells; the pretreatment of H9c2 cells with catalpol can be against H 2 O 2 -induced apoptosis, and the protective effect of catalpol involves the mitochondrial-dependent caspase pathway and is associa...
  • Germacrone

    Germacrone, a natural product isolated from Rhizoma curcuma, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. [1] Germacrone moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 va...
  • Praeruptorin B

    Praeruptorin B has significant P-glycoprotein (Pgp)-inhibition activity.[1] Praeruptorins B and A have LC 50 values of 34.5 and121.2 ug/ml, respectively, in Artemia salina test . [2]
  • Tenuifolin

    Tenuifolin is an effective compound from tenuigenin, is commonly used in traditional Chinese herbal medicine for memory loss, has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.[1] Tenuifolin is one...
  • Linderane

    Linderane (LDR), a furan-containing sesquiterpenoid, is found in Lindera aggregata (Sims) Kosterm, a common traditional Chinese herbal medicine, was characterized as a mechanism-based inactivator of CYP2C9.[1]
  • Bryonolic acid

    Bryonolic acid(BA), isolated in high yield from transformed hairy root cultures of Trichosanthes kirilowii var. Japonica, it exhibits cytotoxic activity to various tumor cells in vitro, independent of cell type. [1] Bryonolic acid can induce a marked increase in the expression of a pha...
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