1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene | CAS:63644-68-8

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene
Price:
CAS No.:	63644-68-8
Catalog No.:	CFN96093
Molecular Formula:	C₁₉H₂₀O₄
Molecular Weight:	312.4 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Curcuma longa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Harzianic acid

Catalog No: CFN00118
CAS No: 157148-06-6
Price: $ /

Petunidin-3-O-galactoside chloride

Catalog No: CFN92042
CAS No: 28500-02-9
Price: $318/5mg

Baicalein

Catalog No: CFN98783
CAS No: 491-67-8
Price: $40/20mg

Arctigenin 4'-O-beta-gentiobioside

Catalog No: CFN90714
CAS No: 41682-24-0
Price: $268/5mg

Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg

Mulberroside F

Catalog No: CFN90794
CAS No: 193483-95-3
Price: $288/10mg

Triptolide

Catalog No: CFN99196
CAS No: 38748-32-2
Price: $118/20mg

Hydrangenol

Catalog No: CFN98745
CAS No: 480-47-7
Price: $ /

Neobavaisoflavone

Catalog No: CFN92222
CAS No: 41060-15-5
Price: $60/20mg

Spinosin

Catalog No: CFN99600
CAS No: 72063-39-9
Price: $80/20mg

Description:

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities, it also has hypoglycemic activity.

Targets:

PARP

In vitro:

J. Enzym. Inhib. Med.Chem., 2015(3):1-6.

Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.[Pubmed: 25068729 ]

Aminomethyl derivatives of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities.
METHODS AND RESULTS:
The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC and HPLF non-malignant cells, which reveals the tumour-selectivity of these aminomethyl derivatives, Mannich bases.
CONCLUSIONS:
Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities.

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene Description

Source:	The rhizomes of Curcuma longa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Antihyperglycemic Compound Library Phenols Compound Library PARP Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.201 mL	16.0051 mL	32.0102 mL	64.0205 mL	80.0256 mL
5 mM	0.6402 mL	3.201 mL	6.402 mL	12.8041 mL	16.0051 mL
10 mM	0.3201 mL	1.6005 mL	3.201 mL	6.402 mL	8.0026 mL
50 mM	0.064 mL	0.3201 mL	0.6402 mL	1.2804 mL	1.6005 mL
100 mM	0.032 mL	0.1601 mL	0.3201 mL	0.6402 mL	0.8003 mL

CFN98645	Hirsutanonol	41137-86-4	346.4	C₁₉H₂₂O₆
CFN97513	Hirsutanonol 5-O-glucoside	93915-36-7	508.5	C₂₅H₃₂O₁₁
CFN96051	(3S,7S)-5,6-Dehydro-4''-de-O-methylcentrolobine	227289-51-2	296.4	C₁₉H₂₀O₃
CFN98383	Centrolobol	30359-01-4	300.4	C₁₉H₂₄O₃
CFN97928	1,7-Bis(4-hydroxyphenyl)hept-6-en-3-ol	1083195-05-4	298.4	C₁₉H₂₂O₃
CFN99088	1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one	1083200-79-6	296.4	C₁₉H₂₀O₃
CFN98955	Platyphyllenone	56973-65-0	296.4	C₁₉H₂₀O₃
CFN96790	1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one	332371-82-1	294.35	C₁₉H₁₈O₃
CFN96302	1,7-Bis(4-hydroxyphenyl)hept-6-en-3-one	1251830-57-5	296.4	C₁₉H₂₀O₃
CFN98060	Rubranol	211126-61-3	332.4	C₁₉H₂₄O₅