1-Cinnamoylpyrrolidine | CAS:52438-21-8

1-Cinnamoylpyrrolidine

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Description:

1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.

Targets:

PAFR

In vitro:

Bioorg Med Chem. 2004 Jul 15;12(14):3885-9.

Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.[Pubmed: 15210155 ]

METHODS AND RESULTS:
In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu(2+). Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-Cinnamoylpyrrolidine (3).
CONCLUSIONS:
Compounds 1-3 represent a structurally new type of DNA strand scission agent.

1-Cinnamoylpyrrolidine Description

Source:	The herbs of Piper nigrum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	1-Cinnamoylpyrrolidine
Price:
CAS No.:	52438-21-8
Catalog No.:	CFN96190
Molecular Formula:	C₁₃H₁₅NO
Molecular Weight:	201.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Piper nigrum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-platelet aggregation Compound Library Alkaloids Compound Library PAFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.9677 mL	24.8385 mL	49.6771 mL	99.3542 mL	124.1927 mL
5 mM	0.9935 mL	4.9677 mL	9.9354 mL	19.8708 mL	24.8385 mL
10 mM	0.4968 mL	2.4839 mL	4.9677 mL	9.9354 mL	12.4193 mL
50 mM	0.0994 mL	0.4968 mL	0.9935 mL	1.9871 mL	2.4839 mL
100 mM	0.0497 mL	0.2484 mL	0.4968 mL	0.9935 mL	1.2419 mL

CFN96136	1-(3,4-Dimethoxycinnamoyl)piperidine	128261-84-7	275.4	C₁₆H₂₁NO₃
CFN96121	3'-Demethoxypiplartine	130263-10-4	287.3	C₁₆H₁₇NO₄
CFN96137	Piplartine	20069-09-4	317.3	C₁₇H₁₉NO₅
CFN96229	1-Cinnamoyl-3-hydroxypyrrolidine	1344876-77-2	217.3	C₁₃H₁₅NO₂
CFN96215	Piperlotine A	389572-70-7	231.3	C₁₄H₁₇NO₂
CFN96227	4'-Demethoxypiperlotine C	807372-38-9	261.3	C₁₅H₁₉NO₃
CFN96220	Piperlotine C	886989-88-4	291.4	C₁₆H₂₁NO₄
CFN96226	Piperlotine D	958296-13-4	291.4	C₁₆H₂₁NO₄
CFN96103	3-Phenyl-1-(pyrrol-1-yl)propan-1-one	112448-69-8	199.3	C₁₃H₁₃NO
CFN96105	1-Cinnamoylpyrrole	252248-89-8	197.2	C₁₃H₁₁NO